摘要
目的 :探讨乳腺癌负性生活事件与细胞免疫、淋巴结转移、组织学类型的关系。方法 :选择 1998年— 2 0 0 0年间住该科治疗并经病理学或细胞学确诊的乳腺癌患者 115例 ,乳腺良性疾病患者 115例 ,按同性别、同职业、文化程度相当、生活习惯相近、年龄相仿的原则分组比较。根据杨德森编制的生活事件量表 (life event scale L ES)对家庭生活、工作学习、社交及其他问题进行对比调查 ,同时检测细胞免疫功能。结果 :乳腺癌组负性生活事件总分值显著高于对照组 (P<0 .0 0 1) ;乳腺癌组CD3(T细胞总数 )明显下降 ,两组差异有显著性 (P<0 .0 0 1) ,而 CD4 (辅助性 T细胞 )、CD8(抑制性 T细胞 )、CD4 与 CD8比值及 NK细胞两组无显著性差异 (P>0 .0 5 ) ;淋巴结转移数与负性生活事件的分值呈正相关 ;不同类型的乳腺癌其细胞免疫指标有显著性差异 (P<0 .0 5 ) ,但与负性生活事件的分值无关 (P>0 .0 5 )。结论 :乳腺癌的发生与负性生活事件关系密切 ;负性生活事件与 T细胞总数下降有关 ,与其他细胞因子的百分比值无关 ;负性生活事件对乳腺癌的淋巴结转移有一定的影响 ;不同类型的乳腺癌其细胞免疫指标有显著性差异。
Objective:To discuss the relationship among breast cancer,negative life event,cell immunity,lymphatic metastasis and histological kind.Methods:Choose 115 cases of patients who are with breast cancer diagnosed by pathology and cytology and 115 cases of galactophore benign sick and cured at our hospital during the period of 1998 to 2000.The patients are grouped and compared in accordance with the principle of same sex,same occupation,similar educational attainments and living custom and age.The comparison and investigation are carried out in accordance with the life,work,study,sociality and others published at Life Event (LES) compiled by Yang Desheng.Meanwhile the immunity function of cell is tested.Results: 1. The total score of negative life event in the group of breast cancer is higher than that of control group remarkably ( P <0.001). 2. CD 3 (total T cell) in the group of breast cancer dropped remarkably. The difference between the two groups is obvious ( P <0.001).Nevertheless CD 4 (auxiliary T cell),CD 8 (inhibitory T cell),the ratio between CD 4 and CD 8 and NK cell in the two groups have no obvious difference ( P <0.05). 3.It appears positive relationship between transfer quantity of lymphatic metastasis and the point value of negative life event. 4.The immunity index of cell at different breast cancers exists difference but has no relationship with the point value of negative life event ( P >0.05).Conclusion:The occurrence of breast cancer has close relationship with negative life event;negative life event has relationship with the drop of total T cell and has no relationship with the percent of other cell gene;negative life event has certain effect to lymphatic metastasis of breast cancer;the immunity index of cell at different breast cancers exists difference.
出处
《肿瘤研究与临床》
CAS
2002年第6期374-376,共3页
Cancer Research and Clinic
关键词
乳腺癌
负性生活事件
实验研究
临床研究
Breast cancer
Negative life event
Cell immunity
Lymphatic metastasis
Histological type
