摘要
目的通过对粘附分子CD44v6在不同生物学行为的口腔癌中表达的检测,探讨口腔癌细胞侵袭和转移的可能机制,评估其作为口腔癌预后判断指标的可行性。方法随机选取具有不同生物学行为的口腔黏膜鳞状细胞癌(SCC)60例、疣状癌(VC)30例和皮肤基底细胞癌(BCC)30例,应用免疫组织化学方法(Envision)对上述病例的外检标本进行CD44v6标记,光镜观察,结果分析。结果CD44v6表达下调在SCC和VC之间无明显差异,而在BCC和SCC、BCC和VC之间均有非常显著差异(P<0.01)。结论CD44v6参与了正常黏膜和皮肤表皮上皮细胞间的同质性粘附,在SCC、VC和BCC中可能更多地参与维持鳞状分化肿瘤细胞的上皮分化特性,与上述肿瘤细胞的生物学行为没有明确的关系。
Objective To investigate a potential mechanism of invasion and metastasis of oral cancers,and the possibility of the adhesion molecules being markers for evaluating the prognosis of oral cancers. Methods Randomly selecting achieved paraffin blocks, including 60 cases of squamous cell carcinoma(SCC), 30 cases of verrucous carcinoma(VC) of oral mucosa and 30 cases of basal cell carcinoma(BCC) of epidermis. Using immunohistochemistry method (Envision) to detect the expression of CD44v6 antibody and observe under light microscope. Results The expression level of CD44v6 protein in SCC had no significant difference between SCC and VC, but significant differences of CD44v6 expression were showed between BCC and SCC(P<0.01), as well BCC and VC(P<0.01). Conclusions CD44v6 takes part in the homogeneous adhesion of normal oral mucosa and epidermis and may play a role in maintaining the characteristics of epithelial differentiation, but it has shown no correlation with the biological behavior of oral cancers.
出处
《上海口腔医学》
CAS
CSCD
2002年第4期353-355,共3页
Shanghai Journal of Stomatology
基金
卫生部科学研究基金(96-2-293)
国家教委骨干教师资助计划的资助(GGJS200004)
关键词
CD44V6
生物学行为
口腔癌
肿瘤侵袭
肿瘤转移
CD44v6
Squamous Cell Carcinoma
Verrucous Carcinoma
Basal Cell Carcinoma
Invasion
Metastasis
Prognosis
