摘要
目的通过对食管癌患者血清骨桥蛋白(OPN)水平的检测,探讨OPN在食管癌辅助诊断、转移和预后监测中的作用。方法采用酶联免疫吸附试验检测食管癌患者和健康志愿者血清OPN。结果食管癌患者血清OPN水平明显高于健康志愿者(P<0.05),食管癌患者有远端转移者血清OPN水平显著高于无转移者(P<0.05),食管癌患者术后血清OPN水平显著下降(P<0.05)。结论血清OPN水平是一个较好的评价食管癌发生、发展的指标,血清OPN检测有助于临床对食管癌治疗效果的评判。
Objective To study the clinic significance of serum OPN levels in esophageal carcinorna patients.Methods Serum OPN levels were performed by ELASA.Results The serum OPN levels in esophageal carcinorna patients were significantly higher than controls（P0.05）.The serum OPN levels in esophageal carcinorna patients with metastasis were significantly higher than patients without metastasis（P0.05）.Furthermore,the serum OPN levels in esophageal carcinorna patients were decreased significantly after operation therapy.Conclusion Detection of serum OPN might be helpful for prognosis for esophageal carcinorna patients.
出处
《重庆医学》
CAS
CSCD
北大核心
2011年第2期145-146,共2页
Chongqing medicine
关键词
骨桥蛋白质
食管肿瘤
治疗
osteopontin
esophageal neoplasms
therapy
