摘要
[目的]系统评价有关骨桥蛋白(osteopontin,OPN)与食管鳞状细胞癌(esophageal squamous cell carcinoma,ESCC)临床病理特征的关系。[方法]检索Pubmed、EMBASE、中国知网、万方、维普等数据库,建库至2018-10-01。按照标准筛选文献并评价质量,以Stata12.0软件行Meta分析。纳入17个病例对照研究,食管癌患者1182例,正常对照者761例。[结果]OPN在食管癌组织与正常食管组织(OR=13.237;95%CI:6.274~27.930)、浸润Ⅰ~Ⅱ组与Ⅲ~Ⅳ组(OR=1.298;95%CI:1.028~1.639)、临床Ⅰ~Ⅱ期组与Ⅲ~Ⅳ期组(OR=1.333;95%CI:1.072~1.656)、淋巴结转移组与非淋巴结转移组(OR=1.386;95%CI:1.146~1.675)均差异有统计学意义意义(P<0.05)。不同性别(OR=0.952;95%CI:0.741~1.222)、年龄(OR=1.069;95%CI:0.822~1.392)及高-中分化组与低分化组(OR=0.892;95%CI:0.701~1.137)癌组织中OPN表达均差异无统计学意义(P>0.05)。OPN阳性者较阴性ESCC患者5年生存率低(HR=1.524;95%CI:1.155~2.011),差异有统计学意义(P<0.05)。[结论]ESCC患者OPN显著高于正常组织,OPN与患者浸润深度、临床分期及淋巴结转移状态等临床病理特征有关,且阳性者生存率降低。
[Objective]To systematically evaluate the relationship between osteopontin(OPN)protein and clinicopathological features in esophageal squamous cell carcinoma(ESCC).[Methods]The case-control studies were conducted to investigate the relationship between the expression of OPN and the clinicopathological features of ESCC.Pubmed,EMBASE,CNKI,Wanfang,Weipu and other databases were searched and the literatures were traced.The search period was set from the build of the database to October 1,2018.The literatures were screened according to the criteria and the quality was evaluated.Meta analysis was performed using Stata 12.0 software.[Results]Seventeen case-control studies were included,including1182 cases of esophageal cancer and 761 cases of normal controls.The results showed that the differences of OPN in the esophageal cancer group and normal esophageal tissue(OR=13.237;95%CI:6.274-27.930),infiltration depthⅠ-Ⅱgroup andⅢ-Ⅳgroup(OR=1.298;95%CI:1.028-1.639),clinicalⅠ-ⅡandⅢ-Ⅳgroups(OR=1.333;95%CI:1.072-1.656),lymph node metastasis and non-lymph node metastasis(OR=1.386;95%CI:1.146-1.675)were all statistically significant(P<0.05).However,there was no significant difference in OPN protein expression between Gender(OR=0.952;95%CI:0.741-1.222),age(OR=1.069;95%CI:0.822-1.392)and high-middle differentiation group and poorly differentiated group(OR=0.892;95%CI:0.701-1.137).The OPN-positive patients had lower 5-year OS than the negative ESCC patients,and the difference was statistically significant(HR=1.524;95%CI:1.155-2.011;P<0.05).[Conclusion]The OPN protein of ESCC patients is significantly higher than that of normal tissues.OPN is related to the clinicopathological features such as depth of invasion,clinical stage and lymph node metastasis status,and the OS of positive patients is decreased.
作者
刘晓波
高子夜
吴卫莉
潘俊
李胜保
童强
LIU Xiao-bo;GAO Zi-ye;WU Wei-li;PAN Jun;LI Sheng-bao;TONG Qiang(Department of Gastroenterology,Taihe Hospital,Hubei University of Medicine,442000 Shiyan,Hubei,China;Department of Oncology,Taihe Hospital,Hubei University of Medicine,442000 Shiyan,Hubei,China)
出处
《临床消化病杂志》
2020年第1期14-20,共7页
Chinese Journal of Clinical Gastroenterology
基金
太和医院精准医学研究重大项目(No:2016JD02)资助。
关键词
食管癌
骨桥蛋白
食管鳞状细胞癌
系统评价
META分析
esophageal carcinoma
osteopontin
esophageal squamous cell carcinoma
systematic review
Meta-analysis
