摘要
为研究长期游泳运动老龄小鼠脂质过氧化水平的降低是否与刺激了松果腺释放褪黑素有关 ,将松果腺切除 1 2月龄昆明种小鼠分为手术组 (n =3 6)、非手术组 (n =3 6)和假手术组 (n =1 2 ) ,前 2组又各分为对照组、60min组和 60min +3 %体质量负荷组 ,对其血清中的MDA浓度进行对比研究。结果 :雄性小鼠非手术组中MDA浓度 60min组及 60min +3 %负荷组均显著低于手术同负荷组 (P <0 .0 5 ,P <0 .0 1 )。雌性小鼠 ,非手术组 60min组MDA浓度显著低于手术组 (P <0 .0 5 )。而在 60min +3 %负荷组 ,手术组要显著低于非手术组 (P <0 .0 5 )。提示 :长期运动训练降低血清脂质过氧化水平 ,可能与交感神经兴奋性升高刺激松果腺内褪黑素的合成和释放有关 ;如果选择负荷不当 ,会对松果腺机能产生抑制 。
The objective was to investigate if melatonin is related with the decrease of MDA by pinealectomy mice during long term aerobic exercise. Pinealectomied 12 month old mice were divided into three groups: the control, the swimming 60 min and the 60 min with 3% body mass; and normal mice also were divided three groups in the same way. After eight weeks swimming, all animals were killed, and their MDA levels in serum were assayed. Results: In male mice MDA decreased significantly in normal mice than in the pinealectomied in the swimming 60 min and the swimming 60 min with 3% body mass. while in female mice, the swimming 60 min group has shown the same results as above, but in the swimming 60 min with 3% body weight group the level MDA in pinealectomied group decreased significantly than in the normal group. Conclusion: long term suitable intensity aerobic exercise can enhance the activity of antioxidase, and it is related with stimulating pineal and releasing melatonin.
出处
《首都医科大学学报》
CAS
2002年第4期313-315,共3页
Journal of Capital Medical University
