摘要
目的:探讨抑郁症患者BDNF表达变化及对疾病严重程度的影响,为临床预防和治疗提供有效依据。方法:选取2014年4月至2016年7月在我院心理科确诊为抑郁症的患者60例作为研究组,选取同期到我院进行健康体检者40例作为对照组,使用汉密尔顿抑郁量表(Hamilton depression rating scale,HAMD)和贝克抑郁自评量表(Beck self-rating depression scale,BDI)对患者进行评定,采用酶联免疫吸附法(ELISA)测定抑郁症患者和健康体检者的血清BDNF水平,分析血清BDNF水平与抑郁症发病之间的相关性。结果:研究组患者HAMD评分、BDI评分显著高于对照组,两组比较具有显著统计学差异(P<0.05);研究组与对照组BDNF含量分别为(854.86±103.27)pg/mL与(1523.12±232.67)pg/mL,研究组显著低于对照组,两组比较具有显著统计学差异(P<0.05)。重度抑郁症患者HAMD评分、BDI评分均高于中度、轻度抑郁症患者及对照组(P<0.05),重度抑郁症患者BDNF水平均显著低于中度、轻度抑郁症患者及对照组(P<0.05);中度抑郁症患者HAMD评分、BDI评分均高于轻度抑郁症患者及对照组(P<0.05),中度抑郁症患者BDNF水平均显著低于轻度抑郁症患者及对照组(P<0.05),轻度抑郁症患者HAMD评分、BDI评分均高于对照组(P<0.05),其BDNF水平均显著低于对照组(P<0.05)。多元回归logistic分析显示,血浆BDNF水平降低是抑郁症发生的危险因素(P>0.05)。结论:抑郁症患者BDNF表达显著降低,且抑郁症患病情况越严重BDNF表达越低,BDNF表达降低是抑郁症发病的危险因素。
Objective:To investigate the change of BDNF expression and its effect on the severity of depression in patients with depression,so as to provide an effective basis for clinical prevention and treatment.Methods:From April 2014 to July 2016,60 patients who confirmed depressive patients in our department of psychology were selected as the study group,and 40 healthy persons were selected as the control group in our hospital for the same period.The Hamilton Anxiety Scale(Hamilton depression rating scale,HAMD) and the self rating depression scale of Beck self-rating depression SC(Beck self-rating depression SC) were used.Ale,BDI)assessed the patients and measured the serum levels of BDNF in patients with depression and health examination by enzyme-linked immunosorbent assay(ELISA),and analyzed the correlation between serum BDNF level and the incidence of depression.Results:The HAMD score and BDI score in the study group were significantly higher than those in the control group.The two groups had significant statistical differences(P<0.05),and the BDNF scores of the study group and the control group were(854.86±103.27) pg/mL and(1523.12±232.67) pg/mL respectively.The study group was significantly lower than the control group,and the two groups had significant statistical differences(P<0.05).The HAMD score and BDI score of patients with severe depression were higher than those of moderate,mild depression and control group(P<0.05).The BDNF level of severe depressive patients was significantly lower than that of moderate,mild depression and control group(P<0.05),and the HAMD score and BDI score of moderate depressive patients were higher than those of mild depression patients and control groups.(P<0.05) the level of BDNF in patients with moderate depression was significantly lower than that of mild depression and control group(P<0.05).The HAMD score and BDI score of mild depressive patients were all higher than those of the control group(P<0.05),and the level of BDNF was significantly lower than that of the control group
作者
温友禄
宁连才
毕研蒙
张婷婷
邓小亮
古婷婷
温金峰
Wen Youlu;Ning Liancai;Bi Yanmeng;Zhang Tingting;Deng Xiaoliang;Gu Tingting;Wen Jinfeng(Department of Psychology,Guangdong 999 Brain Hospital,Guangzhou,Guangdong 510510,China)
出处
《广州医科大学学报》
2018年第3期31-34,共4页
Academic Journal of Guangzhou Medical University
