摘要
目的探讨养血清脑颗粒联合丁苯酞软胶囊治疗轻中度脑梗死的临床疗效。方法选取2017年1月—2018年12月在三门峡市中心医院就诊的92例轻中度脑梗死患者为研究对象,按照随机数字表法将全部患者分为对照组和治疗组,每组各46例。对照组口服丁苯酞软胶囊,200 mg/次,3次/d。治疗组在对照组治疗的基础上温水冲服养血清脑颗粒,4 g/次,3次/d。两组患者连续治疗20 d。观察两组的临床疗效,比较两组的血液流变学、血管内皮功能指标、美国国立卫生研究院卒中量表(NIHSS)评分。结果治疗后,对照组和治疗组的总有效率分别为80.43%、93.48%,两组比较差异有统计学意义(P<0.05)。治疗后,两组全血黏度、血浆黏度、D-二聚体、纤维蛋白原水平均明显降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗后,治疗组的全血黏度、血浆黏度、D-二聚体、纤维蛋白原水平明显低于对照组,两组差异有统计学意义(P<0.05)。治疗后,两组一氧化氮(NO)水平明显升高,内皮素-1(ET-1)、血栓素A2(TXA2)水平均明显降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗后,治疗组的NO水平高于对照组,ET-1、TXA2水平低于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组NIHSS评分显著降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗后,治疗组的NIHSS评分低于对照组,两组差异有统计学意义(P<0.05)。结论养血清脑颗粒联合丁苯酞软胶囊治疗轻中度脑梗死具有较好的临床疗效,可改善血液流变学和血管内皮功能,有助于降低神经功能缺损程度,具有一定的临床推广应用价值。
Objective To explore the clinical effect of Yangxue Qingnao Granules combined with Butylphthalide Soft Capsules in treatment of mild to moderate cerebral infarction.Methods Patients(92 cases)with mild to moderate cerebral infarction in Sanmenxia Central Hospital from January 2017 to December 2018 were randomly divided into control and treatment groups,and each group had 46 cases.Patients in the control group were po administered with Butylphthalide Soft Capsules,200 mg/time,three times daily.Patients in the treatment group were po administered with Yangxue Qingnao Granules on the basis of the control group,4 g/time,three times daily.Patients in two groups were treated for 20 d.After treatment,the clinical efficacies were evaluated,and hemorheology,vascular endothelial function indexes,and NIHSS scores in two groups were compared.Results After treatment,the clinical efficacies in the control and treatment groups were 80.43%and 93.48%,respectively,and there was difference between two groups(P<0.05).After treatment,whole blood viscosity,plasma viscosity,D-dimer,and fibrinogen in two groups were significantly decreased,and the difference was statistically significant in the same group(P<0.05).And the hemorheology indexes in the treatment group were significantly lower than those in the control group,with significant difference between two groups(P<0.05).After treatment,the levels of NO in two groups were significantly increased,but the levels of ET-1 and TXA2 in two groups were significantly decreased,and the difference was statistically significant in the same group(P<0.05).And the vascular endothelial function indexes in the treatment group were significantly better than those in the control group,with significant difference between two groups(P<0.05).After treatment,NIHSS scores in two groups were significantly decreased,and the difference was statistically significant in the same group(P<0.05).And the NIHSS score in the treatment group was significantly lower than those in the control group,with significant diffe
作者
张琦
田金英
ZHANG Qi;Tian Jin-ying(Department of Pharmacy,Sanmenxia Central Hospital,Sanmenxia 472000,China;Neurological ICU,Sanmenxia Central Hospital,Sanmenxia 472000,China)
出处
《现代药物与临床》
CAS
2019年第9期2677-2680,共4页
Drugs & Clinic
