摘要
目的探究百令胶囊联合来氟米特片和醋酸泼尼松片治疗狼疮性肾炎的临床疗效。方法选取2012年12月—2017年3月开封市中心医院收治的126例狼疮性肾炎患者作为研究对象,按随机原则将患者分为对照组(63例)和治疗组(63例)。对照组患者口服来氟米特片,2片/次,1次/d;同时口服醋酸泼尼松片,1mg/(kg?d),2个月后减量至10mg/d。治疗组在对照组的基础上口服百令胶囊,1g/次,3次/d。两组患者均连续治疗6个月。观察两组患者的临床疗效,同时比较治疗前后两组的白蛋白(ALB)、血肌酐(Scr)、24 h尿蛋白定量(24 h UP)、补体C3、红细胞(RBC)和β2-微球蛋白(β2-MG)水平、系统性狼疮性疾病活动度(SLEDAI)积分。结果治疗后,对照组和治疗组的总有效率分别为79.37%、92.06%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组ALB、补体C3和RBC较治疗前明显升高,而Scr、24 h UP和β2-MG较治疗前明显下降,同组治疗前后比较差异具有统计学意义(P<0.05)。治疗后,治疗组ALB、补体C3和RBC较对照组明显升高,Scr、24hUP和β2-MG较对照组明显下降,两组比较差异具统计学意义(P<0.05)。治疗后,两组SLEDAI积分较治疗前明显下降,同组治疗前后比较差异具有统计学意义(P<0.05);且治疗后,治疗组SLEDAI积分较对照组显著降低,两组比较差异具有统计学意义(P<0.05)。结论百令胶囊联合来氟米特片和醋酸泼尼松片治疗狼疮性肾炎具有较好的临床疗效,可改善肾脏功能,降低狼疮性肾炎活动度和不良反应发生率,具有一定的临床推广应用价值。
Objective To explore the clinical efficacy of Corbrin Capsules combined with Leflunomide Tablets and Prednisone Acetate Tablets in treatment of lupus nephritis. Methods Patients(126 cases) with lupus nephritis in Kaifeng Central Hospital from December 2012 to March 2017 were randomly divided into control(63 cases) and treatment(63 cases) groups. Patients in the control group were po administered with Leflunomide Tablets, 2 tablets/time, once daily. At the same time, they were po administered with Prednisone Acetate Tablets, 1 mg/(kg?d), and reduced to 10 mg/d after 2 month. Patients in the treatment group were po administered with Corbrin Capsules on the basis of the control group, 1 g/time, three times daily. Patients in two groups were treated for 6 month. After treatment, the clinical efficacy was evaluated, and ALB, Scr, 24 h UP, complement C3, RBC, and β2-MG levels, and the SLEDAI scoresin two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment group were 79.37% and 92.06%, respectively, and there were differences between two groups(P < 0.05). After treatment, ALB, complement C3, and RBC were significantly increased in two groups, but Scr, 24 h UP, and β2-MG were significantly decreased, and there were differences in the same group(P < 0.05). After treatment, ALB, complement C3, and RBC levels in the treatment group were higher than those in the control group, but Scr, 24 h UP, and β2-MG were lower than those in the control group, and there were differences between two groups(P < 0.05). After treatment, SLEDAI scores in two groups were significantly decreased, and there were differences in the same group(P < 0.05). After treatment, SLEDAI scores in the treatment group were significantly lower than those in the control group, and there were differences between two groups(P < 0.05). Conclusion Corbrin Capsules combined with Leflunomide Tablets and Prednisone Acetate Tablets has clinical curative effect in treatment of lupus nephritis,
作者
李晓勇
李方晓
李斌
LI Xiao-yong;LI Fang-xiao;LI Bin(Department of Nephrotic Rheumatology, Kaifeng Central Hospital, Kaifeng 475000, China)
出处
《现代药物与临床》
CAS
2019年第1期154-158,共5页
Drugs & Clinic
基金
开封市科技发展计划项目(1603007)
