摘要
目的明确健康人群中血清胃蛋白酶原(PG)和胃癌相关肿瘤标志物的分布特征,分析其对健康体检的价值。方法利用Luminex 200多功能流式点阵仪检测958例体检者血清肿瘤标志物及胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)水平,并计算PGⅠ/PGⅡ比值(PGR),同时对各体检者进行C^(13)呼气试验,分析各临床指标间的关系。结果该人群中男性血清PGⅠ水平高于女性,差异有统计学意义(P<0.05);随着年龄的增长,血清PGⅠ、PGⅡ、癌胚抗原(CEA)、糖类抗原199(CA199)和糖类抗原242(CA242)水平逐渐升高,而PGR缓慢下降。该人群中男性C^(13)呼气试验阳性率高于女性,差异有统计学意义(P<0.05);C^(13)呼气试验阳性者血清PGⅠ、PGⅡ水平高于阴性者,PGR低于阴性者,差异均有统计学意义(P<0.05)。结论健康体检人群血清PG的分布与年龄、性别、幽门螺杆菌感染相关,血清肿瘤标志物在胃癌筛查中的作用有限。
Objective To clarify the distribution characteristics of serum pepsinogen(PG)and gastric cancer related tumor markers in the healthy population,and analyse their value in health examination.Methods The levels of serum tumor markers,pepsinogenⅠ(PGⅠ)and pepsinogenⅡ(PGⅡ)were detected in 958 subjects who underwent physical examination by using the Luminex 200 instrument,and the ratio of PGⅠ/PGⅡ(PGR)was calculated.Meanwhile,the C^(13) breath test was carried out,and relationships among these clinical indicators were analysed.Results In this population,The serum level of PGⅠin male subjects was higher than that in female subjects,there was statistically significant difference(P<0.05).The levels of serum PGⅠ,PGⅡ,carcinoembryonic antigen(CEA),carbohydrate antigen 199(CA199)and carbohydrate antigen 242(CA242)were gradually increased with age,while the PGR was slowly decreased with age.The positive rate of C^(13) breath test in male subjects was higher than that in female subjects,there was statistically significant difference(P<0.05).Compared with subjects whose C^(13) breath test results were negative,the serum levels of PGⅠ and PGⅡ were higher,while the PGR was lower in subjects whose C^(13) breath test results were positive(P<0.05).Conclusion The distribution of serum PG might be correlated with age,gender and the infection of Helicobacter pylori in healthy population.It is shown that the effects of tumor markers on gastric cancer screening are limited.
出处
《国际检验医学杂志》
CAS
2016年第5期608-610,共3页
International Journal of Laboratory Medicine
