摘要
炎症性肠病(inflammatory bowel disease,BD)是一类免疫相关性肠道疾病,包括溃疡性结肠炎(ulcerative colitis,UC)、克罗恩病(Crohn’s disease,CD)、未定型结肠炎(indeterminate colitis,IC)3类,其病因和发病机制至今不明,多数研究推测其发病可能与肠道黏膜的免疫系统异常反应、环境因素、遗传易感性和肠道菌群改变等相关。为进一步明确肠道菌群失调与IBD发病机制的相关性,本文就IBD患者肠道菌群失调特征与其可能的发生发展机制进行综述。
Inflammatory bowel disease(IBD)is an immune-related intestinal inflammatory disease,which is clinically divided into 3 categories:ulcerative colitis(UC),Crohn’s disease(CD),and indeterminate colitis(IC).Although its pathogenesis is still unclear,most studies speculate that the pathogenesis of IBD has the relation with the abnormal response of intestinal mucosal immune system,environmental factors,genetic susceptibility and intestinal flora dysbiosis.In recent years,the relationship between intestinal flora dysbiosis and the pathogenesis of IBD has become a research hotspot.Therefore,this article reviews the characteristics of intestinal flora dysbiosis and its possible mechanism in patients with IBD.
作者
陈娇娇
周莹群
CHEN Jiao-jiao;ZHOU Ying-qun(Department of Gastroenterology,Shanghai Tenth People’s Hospital of Tongji University,Shanghai 200072,China)
出处
《世界临床药物》
CAS
2019年第5期324-328,共5页
World Clinical Drug
基金
上海市第十人民医院国家自然培育基金项目(编号:SYGZRPY2017003)
关键词
炎症性肠病
肠道菌群
发病机制
inflammatory bowel disease
intestinal flora microbiota
pathogenesis
