摘要
目的分析比阿培南对丙戊酸钠血药浓度的影响。方法针对临床病例术后使用比阿培南抗感染后出现口肌痉挛泵入丙戊酸钠,其次日检测丙戊酸钠浓度仅为8.53μg/ml。检索相关文献,总结分析比阿培南对丙戊酸钠血药浓度的影响。结果丙戊酸钠无论静脉还是口服给药,与比阿培南联用,丙戊酸钠血药浓度均显著降低,降幅可达42.64%~84.48%。结论丙戊酸钠与比阿培南联用,丙戊酸钠浓度显著降低,临床应避免两者联用。
Objective To observe the effect of biapenem on decreasing the serum concentration of sodium valproate and to review the related literatures. Methods The patients, who used biapenem as anti-infection was given the sodium valproate for occurred muscle spasm relief. In second day, the sodium valproate concentration was detected. The influence of biapenem on the serum concentration of sodium valproate was analyzed base on the related literatures. Results The serum concentration of sodium valproate was significantly decreased while it combined with biapenem, no matter intravenous or oral administration. The decline rate was 42.64% to 84.48%. Conclusion Biapenem can decrease the serum concentration of sodium valproate significantly, which is necessary to avoid the combination of two drugs in clinic.
出处
《世界临床药物》
CAS
2017年第11期772-775,共4页
World Clinical Drug
基金
北京市政府项目-老年重大疾病关键技术研究(编号:20170026)
关键词
丙戊酸钠
比阿培南
血药浓度
sodium valproate
biapenem
serum concentration
