摘要
表面分子印迹技术是在载体表面上发生聚合反应,将分子识别位点建立在载体的外层或者表面。从而使表面分子印迹聚合物具有结合速度快、识别选择性强、结合容量高、提高印迹材料的效率等优点。近年来表面分子印迹技术在药物分离分析中的应用引起人们的关注。简要介绍了表面分子印迹聚合物的原理及4种制备方法(溶胶-凝胶法、接枝共聚法、牺牲载体法、聚合加膜法、活性可控自由基聚合法),并对其在药物分离分析的4个方面(中药提取分离中;药物传感器方面;手性药物拆分中;药物释放中)的应用进行了综述。
The surface molecular imprinting technique is to polymerize and establish the molecular recognition site on the outer layer or surface of the carrier. As a result, the surface molecularly imprinted polymers have the advantages of fast binding speed, strong identification selectivity, high binding capacity and improved efficiency of imprinted materials. In this paper, the principle of surface molecularly imprinted polymers and four preparation methods(sol-gel method, graft copolymerization method, sacrificial carrier method, polymerization plus membrane method, active controllable free radical polymerization) were briefly introduced. Four aspects of drug separation and analysis(traditional Chinese medicine extraction and separation;drug sensors;chiral drug resolution;the application) in drug release was reviewed.
作者
何红芳
李延斌
余佳照
胡译之
HE Hongfang;LI Yanbin;YU Jiazhao;HU Yizhi(Department of Chemistry,North University of China,Taiyuan 030051,China)
出处
《功能材料》
EI
CAS
CSCD
北大核心
2019年第3期3064-3070,3080,共8页
Journal of Functional Materials
基金
国家自然科学基金青年基金资助项目(21404093)
关键词
表面分子印迹技术
手性药物
分离
应用
surface molecular imprinting technique
chiral drugs
separation
application
