摘要
目的:探讨STAT3、Cyclin D1、ADAM12表达在胃癌发生、发展中的作用及其临床意义。方法:采用免疫组化检测癌前疾病、癌前病变、早期胃癌、进展期胃癌组织及转移淋巴结组织中STAT3、Cyclin D1、ADAM12的表达,分析这3个基因表达在胃组织癌变过程中的作用。结果:STAT3阳性表达率及Cyclin D1阳性表达率在早期及进展期胃癌、转移淋巴结中表达增高,差异有统计学意义(P<0.01);Cyclin D1、STAT3蛋白表达与胃癌的分化程度及淋巴结转移呈正相关(P<0.05);ADAM12蛋白表达阳性率在各组间均无统计学差异(P>0.05);STAT3与Cyclin D1表达呈正相关(r=0.305,P<0.01)。结论:STAT3、Cyclin D1与胃癌的发展及侵袭转移相关,STAT3可能通过上调Cyclin D1的表达促进胃癌的发展及转移。
Objective:To investigate the role of STAT3,Cyclin D1 and ADAM12 expression in the occurrence and development of gastric cancer and its clinical significance.Methods:The expression of STAT3,Cyclin D1 and ADAM12 in precancerous diseases,precancerous lesions,early gastric cancer,advanced gastric cancer and metastatic lymph nodes was detected by immunohistochemistry,and their roles in the carcinogenesis of gastric tissue were analyzed.Results:The positive expression rates of STAT3 and Cyclin D1 were significantly higher in early and advanced gastric cancer and metastatic lymph nodes(P<0.01).The expression of Cyclin D1 and STAT3 protein was positively correlated with the differentiation degree and lymph node metastasis of gastric cancer(P<0.05).The positive rate of ADAM12 protein expression was not significantly different among the groups(P>0.05).STAT3 is positively correlated with Cyclin D1 expression(r=0.305,P<0.01).Conclusion:STAT3 and Cyclin D1 are related to the development,invasion and metastasis of gastric cancer.STAT3 may promote the development and metastasis of gastric cancer by up-regulating the expression of Cyclin D1.
作者
陈云
张晓梅
谷欢
严璐
CHEN Yun;ZHANG Xiaomei;GU Huan(Department of Gastroenterology,Xiangya Hospital of Central South University,Changsha 410000,China)
出处
《华夏医学》
CAS
2019年第2期1-5,共5页
Acta Medicinae Sinica
基金
湖南省财政厅项目资助(湘财教指2014254)
