摘要
胃癌癌前病变(precancerous lesions of gastric cancer,PLGC)是胃癌发生和发展过程中的一个重要阶段,早期发现和干预是防控胃癌的重要手段.在PLGC的形成过程中,DNA甲基化、微卫星不稳定性、p53以及幽门螺杆菌(Helicobacter pylori,H.pylori)感染等占有重要位置.鉴于胃癌的高度恶性,且其病因发病机制尚未完全阐明,实施针对病因的一级预防比较困难.本文就目前PLGC发病机制、防治对策等问题进行总结,以便于临床医师对胃癌前病变进行密切的监测及有效的干预.
The development of precancerous lesions of gas- tric cancer is a critical stage of the evolution of gastric cancer. Early detection and intervention for these lesions are of considerable significance in reducing the morbidity of gastric cancer. The development of precancerous lesions of gastric cancer is controlled by multiple factors such as Helicobacter priori infection, DNA methylation, microsatellite instability, and p53 status. Be- cause of high malignancy and unclear etiology of gastric cancer, there are certain difficulties in carrying out successful primary prevention. This review aims to review the recent advances in understanding the pathogenesis of and preven- tive strategies for gastric precancerous lesions.
出处
《世界华人消化杂志》
CAS
北大核心
2012年第20期1807-1812,共6页
World Chinese Journal of Digestology
基金
江苏省中医药管理局基金资助项目
No.JD11040~~
关键词
胃癌
癌前病变
上皮内瘤变
Gastric cancer
Precancerous lesions of gastric cancer
Intraepithelial neoplasia
