摘要
目的研究微小染色体维持蛋白2(MCM2)在鼻咽癌中表达以及同鼻咽癌临床分期、颈淋巴结转移、病理类型、远处转移等的关系。方法对62例鼻咽癌标本应用免疫组化法研究、分析MCM2基因的表达情况。结果①有远处转移组的MCM2表达水平明显高于无远处转移组;②MCM2的表达水平与临床分期呈正相关;③MCM2表达在未分化癌组中高于角化性鳞癌组;④MCM2的表达在有无颈淋巴结转移、年龄、性别组间无明显差异。结论 MCM2表达的程度与鼻咽癌的临床分期相关;MCM2的高表达可能是鼻咽癌远处转移的因素之一;MCM2表达的水平可能是鼻咽癌预后评估的重要参考指标。
Objective To study the correlations of the immunohistochemical expression of mini chromosome maintenance protein 2(MCM2) in nasopharyngeal carcinoma with clinical stage,cervical lymph node metastasis,pathological type and distant metastasis.Methods The expression of MCM2 gene was studied in 62 cases of nasopharyngeal carcinoma by immunohistochemistry.Results① The expression level of MCM2 in primary nasopharyngeal carcinoma with distant metastasis was higher than in that without distant metastasis.② MCM2 expression was positively correlated with clinical stage.③ MCM2 expression in anaplastic carcinoma was higher than in keratinizing squamous cell carcinoma.④ MCM2 expression showed no significant differences regarding age,gender,and cervical lymph node metastasis.Conclusion MCM2 expression is associated with the clinical stage of nasopharyngeal carcinoma.The increased expression of MCM2 may be one of the factors for distant metastasis of nasopharyngeal carcinoma.The degree of MCM2 expression may be an important reference index for the prognosis evaluation of nasopharyngeal carcinoma.
出处
《中国组织化学与细胞化学杂志》
CAS
CSCD
2016年第2期148-152,共5页
Chinese Journal of Histochemistry and Cytochemistry
关键词
微小染色体维持蛋白2
鼻咽癌
远处转移
Mini Chromosome Maintenance Protein 2
nasopharyngeal carcinoma
distant metastasis
