摘要
背景与目的:诱导化疗在舌鳞癌治疗中具有重要作用,本研究目的在于探讨单药平阳霉素诱导化疗在T2舌鳞癌治疗中的应用价值。方法:回顾性分析单纯手术及单药平阳霉素诱导化疗加手术分别治疗36例舌鳞癌T2病变患者后,对其生存及复发情况的影响。结果:单纯手术组及诱导化疗加手术组的5年生存率分别为81.46%和57.14%,差异有显著性(P=0.0229);区域/局部复发率分别为22.2%和33.3%,中位复发时间分别为20和24个月。对Ⅱ、Ⅲ期及Ⅳ期患者,两种治疗措施的5年生存率无显著差异(P=0.0949;P=0.0739)。在Ⅲ及Ⅳ期病变中,单纯手术组和诱导化疗加手术组的区域/局部复发率分别为12.5%和35.7%,中位复发时间分别为12和12.8个月。结论:单药平阳霉素诱导化疗对舌鳞癌T2病变的治疗价值不大。不管是早T2病变还是晚T2病变,它对患者的5年生存率没有明显影响,对局部控制率的影响仍有待进一步观察。
Background & Objective:Induction chemotherapy play an important role in treatment of the patients with tongue squamous cell carcinoma.This study was designed to evaluate the role of induction chemotherapy with single agent bleomycin A5 in treating stage T2 tongue squamous cell cancinoma. Methods:The authors retrospectively analyzed the influence of surgery and induction chemotherapy with single agent bleomycin A5 plus surgery on survival rate and locoregional control among 72 patients with tongue squamous cell carcinoma. Results:The 5 year survival rates were 81.46% and 57.14% respectively for the group of surgery alone and the group of induction chemotherapy plus surgery,the difference between the two groups were significant (P=0.0229). The rates of locoregional recurrence were 22.2%,33.3% and the medial time of recurrence was 20,24 months respectively in the two groups. For the patients in stageⅡ and stageⅢ plus stageⅣ,there was no difference between the two groups for the 5 year survival rate (P=0.0949;P=0.0739). For the patients in stage Ⅲ plus stageⅣ,the rates of locoregional recurrence were 12.5%,35.7% and the medial time of recurrence was 12,12.8 months,respectively,in the two groups. Conclusions:It has no significant role in treatment of the patients with stage T2 tongue squamous cell carcinoma for single agent bleomycin A5. Induction chemotherapy using single agent bleomycin A5 did not improve the 5 year survival rate for early or late primary lesions. The impact on the control rate of locoregional recurrence would be studied further for single agent bleomycin A5.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
2002年第12期1372-1375,共4页
Chinese Journal of Cancer
关键词
治疗
舌鳞癌
诱导化疗
预后
Tongue squamous cell carcinoma
Induction chemotherapy
Prognosis
