摘要
目的 探讨序贯与同步放化疗分别治疗直肠癌的临床疗效及毒副作用.方法 选取90例直肠癌患者,根据疾病分期标准分为Ⅱa期21例（Ⅱa组）、Ⅲa期24例（Ⅲa组）、Ⅱb期23例（Ⅱb组）、Ⅲb期22例（Ⅲb组）.Ⅱa组和Ⅲa组患者使用序贯放化疗治疗,Ⅱb组和Ⅲb组使用同步放化疗治疗,分别比较患者的临床疗效和毒副反应发生情况.结果 所有患者的1年和3年随访无1例失访及死亡情况.Ⅱa组和Ⅱb组的1年和3年的总生存时间（OS）与无进展生存时间（PFS）差异均无统计学意义（均P＞0.05）;Ⅲa组与Ⅲb组的1年OS差异无统计学意义（P＞0.05）,1年PFS、3年OS以及3年PFS差异均有统计学意义（χ2=3.993、4.224、4.304,均P＜0.05）;Ⅱa组＋Ⅲa组的毒副反应发生率（28.89％）与Ⅱb组＋Ⅲb组的毒副反应发生率（51.11％）差异有统计学意义（χ2=4.629,P＜0.05）,对于各系统具体的毒副反应发生率差异无统计学意义（P＞0.05）.结论 与序贯放化疗相比,在直肠癌的治疗中,同步放化疗能有效延长患者的OS和PFS,虽增加了患者治疗后的毒副反应,但仍在患者可接受范围内,临床上具有更好的应用价值.
Objective To investigate the clinical efficacy and side effects of sequential and concurrent chemoradiation in the treatment of colorectal cancer.Methods 90 patients with colorectal cancer were divided into ⅡAof 21 cases （Ⅱa group）,Ⅲa of 24 cases （Ⅲa group）,Ⅱb of 23 cases （Ⅱb group）,Ⅲb of 22 cases （Ⅲa group） according to the stage of the disease.Group Ⅱa and Ⅲa were treated by sequential chemoradiation therapy,Ⅱb group and Ⅲb group were treated by concurrent chemoradiation therapy.The clinical efficacy and toxicity were observed and compared.Results All patients were followed up at 1 and 3 years,no one lost and died.1-year and 3-year OS and PFS between group Ⅱa and group Ⅱb had no significant differences （P 〉 0.05）.1-year OS had no significant difference between Ⅲa group and Ⅲb group （P 〉 0.05）,1-year PFS,3-year OS and PFS had significant differences （χ2 =3.993,4.224,4.304,all P 〈 0.05）.The incidence rate of toxicities between Ⅱa group ＋Ⅲa group （28.89%） and group Ⅱb＋ Ⅲb （51.11%） had significant difference （χ2 =4.629,P 〈 0.05） ; while for each system specific incidence rate of side effects had no significant difference （P 〉 0.05）.Conclusion Compared with sequential chemotherapy in the treatment of colorectal cancer,concurrent chemoradiotherapy can effectively prolong overall survival and progression-free survival time,and can reduce the costs of treating,although increasing the treatment toxicity,but still within the acceptable range of patients,it has better application value in clinical.
出处
《中国基层医药》
CAS
2014年第13期1924-1926,共3页
Chinese Journal of Primary Medicine and Pharmacy
关键词
直肠肿瘤
放射疗法
药物疗法
Rectal neoplasms
Radiotherapy
Drug therapy
