摘要
目的 探讨饱和脂肪酸或不饱和脂肪酸与成年女性乳腺癌发生率之间的关系,为乳腺癌的预防与管理提供证据。方法 基于国家健康与营养检查调查(NHANES)进行横断面分析,纳入2013—2018年共3个周期的成年女性参与者,收集膳食数据和乳腺癌资料。采用多因素logistic回归探讨膳食饱和脂肪酸与不饱和脂肪酸对乳腺癌发生率的影响,构建限制性立方样条模型(RCS)分析其剂量-反应关系。结果 共纳入1 197例成年女性参与者,其中发现乳腺癌患者63例(5.26%)。与对照组相比,乳腺癌患者总饱和脂肪酸、总单不饱和脂肪酸、总多不饱和脂肪酸摄入量、ω-6/ω-3不饱和脂肪酸摄入比例差异无统计学意义(P>0.05),两组ω-3、ω-6不饱和脂肪酸摄入差异具有统计学意义(P<0.05)。多因素logistic回归结果显示,在调整年龄、种族、是否吸烟、是否合并高血压等协变量后,ω-3(OR=0.574)和ω-6不饱和脂肪酸(OR=0.884)摄入量的增加均是成年女性患者发生乳腺癌的独立危险因素(P<0.05)。RCS模型显示,ω-3和ω-6不饱和脂肪酸摄入量与成年女性乳腺癌发生率呈现负向非线性关系,且趋势具有统计学意义(P<0.01)。结论 成年女性ω-3、ω-6不饱和脂肪酸摄入量的增加可以降低乳腺癌风险,合理的脂肪酸摄入结构可能有助于降低乳腺癌的风险。
Objective To explore the relationship between saturated or unsaturated fatty acids and the incidence of breast cancer in adult women,so as to provide evidence for the prevention and management of breast cancer.Methods Cross sectional analysis was conducted based on the National Health and Nutrition Examination Survey(NHANES).Adult female participants in three cycles from 2013 to 2018 were included,and dietary data and breast cancer data were collected.Multivariate logistic regression was used to explore the effect of dietary saturated fatty acids and unsaturated fatty acids on the incidence of breast cancer,and a restricted cubic spline(RCS)model was constructed to analyze the dose response relationship.Results A total of 1197 adult female participants were included,and 63 of whom were found to have breast cancer(5.26%).Compared with the control group,the intake of total saturated fatty acids,total monounsaturated fatty acids and total polyunsaturated fatty acids in breast cancer patients had no significant difference(P>0.05),while the intake ofω-3 andω-6 unsaturated fatty acids in the two groups had significant difference(P<0.05).Multivariate logistic regression results showed that after adjusting for age,race,smoking,hypertension and other covariates,the increased intake ofω-3(OR=0.574)andω-6 unsaturated fatty acids(OR=0.884)were independent risk factors for breast cancer in adult female patients(P<0.05).The RCS model showed that the intake ofω-3 andω-6 unsaturated fatty acids had a negative nonlinear relationship with the incidence of breast cancer in adult women,and the trend was statistically significant(P<0.01).Conclusion The increased intake ofω-3 andω-6 unsaturated fatty acids in adult women can reduce the risk of breast cancer,and a reasonable intake structure of fatty acids may help to reduce the risk of breast cancer.
作者
徐泰
张思明
范苑林
丘冬琴
朱俊强
吴媛
罗皓月
Xu Tai;Zhang Siming;Fan Yuanlin;Qiu Dongqin;Zhu Junqiang;Wu Yuan;Luo Haoyue(Department of Breast Surgery,Meizhou People’s Hospital,Meizhou Guangdong 514031,China)
出处
《遵义医科大学学报》
2024年第12期1222-1228,共7页
Journal of Zunyi Medical University
基金
梅州市社会发展科技计划项目(NO:2022B38)。
关键词
饱和脂肪酸
不饱和脂肪酸
乳腺癌
美国国家健康与营养调查
横断面研究
saturated fatty acids
unsaturated fatty acids
breast cancer
national health and nutrition examination survey
cross sectional study
