摘要
头颈部鳞状细胞癌(head and neck squamous cell carcinoma,HNSCC)是一种极具侵袭性的恶性肿瘤,尽管患者接受了标准治疗,但局部复发和远处转移的风险仍较高,导致预后不佳。近年来,免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)在多种实体瘤治疗中展现出显著疗效,并彻底改变了多种晚期肿瘤的治疗模式。然而,在部分患者中免疫治疗非但未能为患者带来生存获益,反而导致肿瘤病灶在短时间内快速生长,临床上称为免疫超进展(hyperprogressive disease,HPD)。目前,关于HPD的机制、临床预测指标及实际应对策略的研究相当有限。本文着眼于HNSCC并回顾有关HPD的研究现状,以期为免疫治疗的优化提供科学依据。
Head and neck squamous cell carcinoma(HNSCC)is a highly invasive malignant tumor.Although patients receive standard treatment,the risk of local recurrence and distant metastasis remains high,resulting in a poor prognosis.In recent years,immune checkpoint inhibitors(ICIs)have shown significant efficacy in the treatment of a variety of solid tumors and have changed the treatment modality for many advanced tumors.However,in some patients,immunotherapy not only failed to bring survival benefits but also led to the rapid growth of tumor lesions in a short period of time,which is clinically known as hyperprogressive disease(HPD).There is limited research on the mechanism,clinical predictors,and coping strategies for immunotherapy-related hyperprogression.Therefore,this article focuses on HNSCC and reviews the current research on HPD to provide a scientific basis for optimizing immunotherapy.
作者
黄秋艺
徐凌峰
樊倩妤(综述)
陈健(审校)
Qiuyi Huang;Lingfeng Xu;Qianyu Fan;Jian Chen(Department of Head and Neck Surgery,Hubei Cancer Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430079,China)
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2024年第21期1125-1130,共6页
Chinese Journal of Clinical Oncology
基金
国家癌症中心攀登基金临床研究项目(编号:NCC201917B02)资助。
关键词
头颈部鳞状细胞癌
免疫治疗
免疫检查点抑制剂
超进展
head and neck squamous cell carcinoma(HNSCC)
immunotherapy
immune checkpoint inhibitors(ICIs)
hyperprogressive disease(HPD)
