摘要
目的探讨双歧杆菌辅助治疗合并2型糖尿病的乙型肝炎肝硬化患者的临床疗效,以及对患者肝功能、免疫功能及血糖的影响。方法选取安徽医科大学第一附属医院2020年3月至2024年3月诊治的138例合并2型糖尿病的乙型肝炎肝硬化患者为研究对象,采用随机数字法将其分为试验组和对照组,每组各69例。2组患者均予常规抗病毒、保护肝功能、降低转氨酶、门冬胰岛素降血糖等治疗,试验组患者加服双歧杆菌乳杆菌三联活菌片。2组均连续治疗观察3个月。结果与治疗前比较,2组患者血糖均控制在正常范围之内,丙氨酸转氨酶(glutamic pyruvic transaminase,ALT)、天冬氨酸转氨酶(glutamic oxaloacetic transaminase,AST)、总胆红素(total bilirubin,TBIL)、糖化血红蛋白水平均得到明显改善,差异均具有统计学意义(P均<0.05)。治疗后,2组患者CD4^(+)T淋巴细胞、CD8^(+)淋巴细胞、CD4^(+)/CD8^(+)、前白蛋白等水平均较治疗前升高,且试验组优于对照组(P均<0.05)。试验组总有效率显著高于对照组(95.65%vs.84.05%,P=0.024)。与治疗前相比,2组患者TBIL、AST、ALT、水平均显著降低,前白蛋白水平则显着升高(P均<0.05);T淋巴细胞亚群CD4^(+)、CD8^(+)水平及CD4^(+)/CD8^(+)均有改善,且试验组上述指标改善更显著(P均<0.05)。实验组总有效率高于对照组(P=0.024),且并发症的发生率明显低于对照组(P=0.043)。结论双歧杆菌辅助治疗合并2型糖尿病的乙型肝炎肝硬化,可促进肝功能恢复,改善患者免疫功能,有效控制血糖,降低并发症发生率,有效缓解患者的临床症状,值得临床推广。
Objective To investigate the clinical efficacy of bifidobacterium in the adjuvant treatment of hepatitis B cirrhosis patients with the Type 2 Diabetes Mellitus(T2DM)and its effects on liver function,immune function and blood glucose.Methods A total of 138 cases of hepatitis B cirrhosis with diabetes mellitus admitted to The First Affiliated Hospital of Anhui Medical University from March 2020 to March 2024 were randomly divided into experimental group and control group,with 69 cases in each group.Both groups were given symptomatic treatment such as conventional antiviral,liver protection,enzyme lowering,insulin aspartate to control blood sugar,etc.The experimental group additionally recevied bifidobacterium Lactobacillus triple viable tablet.Both groups were treated and observed continuously for 3 months.Results Compared with before treatment,blood glucose in 2 groups was controlled within the normal range,ALT,AST,TBIL,HbA1c levels were significantly improved,with significant differences(P<0.05).After treatment,the levels of CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)and Pro-ALB in both groups were higher than those before treatment,and the experimental group was better than the control group(P<0.05).The total effective rate of the experimental group was significantly higher than that of the control group(95.65%vs.84.05%,P<0.05).Total bilirubin(TBIL),aspartate aminotransferase(AST),alanine aminotransferase(ALT)and prealbumin(Pro-ALB)were significantly decreased in 2 groups(P<0.05).The levels of CD4^(+)、CD8^(+)and CD4^(+)/CD8^(+)of T lymphocyte subsets were improved,and the above indexes were improved more significantly in the experimental group(P<0.05).The incidence of complications in the experimental group was significantly lower than that in the control group(P<0.05).Conclusion Bifidobacterium adjuvant therapy for hepatitis B cirrhosis complicated with diabetes can improve liver function,promote liver function recovery,improve immune function,effectively control blood sugar,reduce complication rate,and effectively a
作者
付伯康
刘玮
FU Bokang;LIU Wei(School of Public Health,Anhui Medical University,Hefei 230032,China)
出处
《传染病信息》
2024年第6期497-501,共5页
Infectious Disease Information
关键词
乙型肝炎肝硬化
双歧杆菌属
肝功能
免疫功能
2型糖尿病
hepatitis B cirrhosis
bifidobacterium
liver function
immune function
type 2 diabetes mellitus
