摘要
目的:探讨西红康辅助治疗2型糖尿病肾病(DN)Ⅲ期,气阴两虚夹瘀证的疗效以及对血清高敏C反应蛋白(hs-CRP)、肿瘤坏死因子(TNF)-α水平的影响及抗氧化作用。方法:选取本院收治DN患者96例,按随机数字表法分为对照组和观察组,各48例。两组给予常规治疗措施;对照组患者接受还原型谷胱甘肽注射液,1.8 g/次,1次/d;观察组在对照组治疗基础上采取西红康辅助治疗,每日l剂,2次/d。连续治疗3个月,比较两组血糖水平、肾功能、临床疗效、血清hs-CRP、TNF-α、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、丙二醛(MDA)水平。结果:两组患者治疗后空腹血糖(FPG)、糖化血红蛋白(HbA1c)、血肌酐(SCr)、血尿素氮(BUN)、24h尿蛋白均明显下降(P<0.01)。观察组患者治疗后SCr(76.33±9.05)μmol/L、BUN(5.95±0.71)mmol/L、24h尿蛋白(1.61±0.22)g/d显著低于对照组[(79.09±9.93)μmol/L,(7.16±1.12)mmol/L,(1.78±0.27)g/d](P<0.01)。观察组的总有效率87.50%明显高于对照组68.75%(P<0.05)。观察组治疗后血清hs-CRP(4.04±0.52)ng/L、TNF-α(6.43±0.82)ng/L、MDA(4.49±0.67)μmol/L水平明显低于对照组[(4.51±0.62)ng/L,(13.99±1.93)ng/L,(7.31±0.97)μmol/L],SOD(52.81±7.3)IU/ml,GSH-Px(10.93±1.83)g/L水平明显高于对照组[(28.84±4.34)IU/ml,(8.83±`1.17)g/L](P<0.01)。结论:西红康辅助治疗2型糖尿病肾病Ⅲ期气阴两虚夹瘀证可有效改善患者的血糖水平和肾功能,提高临床疗效,抑制微炎症水平和抗氧化作用可能与其疗效有关。
Objective:To investigate the efficacy of adjuvant therapy of Xihongkang in treating type 2 diabetic nephropathyⅢphase with syndrome of Qiyin Liangxu Jiayu type and its effect on serum levels high-sensitivity C-reactive protein(hs-CRP)and tumor necrosis factor(TNF)-αand antioxidant role.Methods:96 DN patients were selected in our hospitaland divided into the control group and the observation group with 48 cases in each group according to the random number table method.The two groups were given with routine treatment referring to the guidelines.The control group received reduced glutathione injection(1.8 g/time and 1 time/day).On the basis of treatment in the control group,the observation group was treated with Xihongkang(l dose/d and 2 times/d).After 3 months’treatment,blood glucose level,renal function,the clinical efficacy,serum levels of hs-CRP,TNF-α,SOD,GSH-Px,MDA were compared in two groups.Results:Fasting blood glucose(FPG),glycosylated hemoglobin(HbA1 c),serum creatinine(SCr),blood urea nitrogen(BUN),and 24 h urine protein in both groups were significantly decreased after treatment(P<0.01).After treatment,SCr(76.33±9.05)μmol/L,BUN(5.95±0.71)mmol/L,and 24 h urine protein(1.61±0.22)g/d in the observation group were significantly lower than those in the control group[(79.09±9.93)μmol/L,(7.16±1.12)mmol/L,(1.78±0.27)g/d](P<0.01).The total effective rate of the observation group(87.50%)was statistically higher than the control group(68.75%)(P<0.05).Serum levels of hs-CRP(4.04±0.52)ng/L,TNF-α(6.43±0.82)ng/L,and MDA(4.49±0.67)μmol/L in the observation group were significantly lower,SOD(52.81±7.3)IU/ml and GSH-Px(10.93±1.83)g/L were significantly higher,than those in the control group[(4.5±0.62)ng/L,(13.99±1.93)ng/L,(7.31±0.97)μmol/L,(28.84±4.34)IU/ml,(8.83±1.17)g/L](P<0.01).Conclusion:Adjuvant therapy of Xihongkang in treating type 2 diabetic nephropathyⅢphase with syndrome of Qiyin Liangxu Jiayu type can effectively improve the patient’s blood sugar levels and renal function,increase
作者
玉山江·艾克木
哈丽达·木沙
地丽尼嘎尔
Yushanjiang·Aikemu;Halida·Musha;Dilinigaer(Affiliated Hospital of Traditional Chinese Medicine of Xinjiang Medical University,Urumqi 830000)
出处
《陕西中医》
2020年第3期338-341,共4页
Shaanxi Journal of Traditional Chinese Medicine
基金
新疆自治区自然科学基金(少数民族特培)资助项目(2018D01C189).
