摘要
目的探讨胃癌根治术后感染对患者循环肿瘤细胞(CTC)及肿瘤标志物水平的影响。方法回顾性病例系列研究。选取2020年1月至2023年12月西安市长安医院收治的100例行胃癌根治术的患者。根据术后是否发生感染, 将患者分为感染组和非感染组。比较两组患者一般临床资料、术后第3天CTC阳性率及外周血肿瘤标志物水平。结果 100例胃癌根治术患者中有21例(21%)发生术后感染, 主要为呼吸道感染(38.10%, 8/21)和手术部位感染(23.8%, 5/21)。感染组的手术时间长于非感染组[(3.4±1.0)h比(3.0±0.4)h], 术中出血量多于非感染组[(415±93)ml比(370±75)ml], 差异均有统计学意义(均P<0.05)。术后第3天感染组CTC阳性率及白细胞计数、中性粒细胞与淋巴细胞比值、糖类抗原153(CA153)、糖类抗原199(CA199)、癌胚抗原(CEA)水平均高于非感染组, 差异均有统计学意义(均P<0.05)。术后第3天感染组胃泌素和胃动素水平均低于非感染组, 差异均有统计学意义(均P<0.05)。结论胃癌根治术后感染引起患者体内CTC阳性率及外周血CA153、CA199、CEA水平升高, 影响患者胃肠功能恢复。
Objective:To investigate the effects of infection on circulating tumor cells(CTC)and tumor markers levels in patients after radical gastrectomy.Methods:A retrospective case series study was conducted.A total of 100 patients who underwent radical gastrectomy admitted to Chang'an Hospital in Xi'an from January 2020 to December 2023 were selected.The patients were divided into the infection group and the non-infection group according to whether the patients were infected or not after surgery.The general clinical data,CTC positive rate on the third day after surgery and peripheral blood tumor markers levels between the 2 groups were compared.Results:Among 100 gastric cancer patients who underwent radical gastrectomy,21 cases(21%)developed postoperative infection,mainly including respiratory infection(38.10%,8/21)and surgical site infection(23.8%,5/21).The infection group experienced longer surgery durations[(3.4±1.0)h vs.(3.0±0.4)h]and more intraoperative blood loss[(415±93)ml vs.(370±75)ml]compared to the non-infection group,and the differences were statistically significant(all P<0.05).The positive rate of CTC,white blood cells,neutrophil-to-lymphocyte ratio,carbohydrate antigen 153(CA153),carbohydrate antigen 199(CA199),and carcinoembryonic antigen(CEA)levels in the infection group were higher than those in the non-infection group on the third day after surgery,and the differences were significantly significant(all P<0.05).Levels of gastrin and motilin in the infection group were lower than those in the non-infection group on the third day after surgery,and the differences were statistically significant(all P<0.05).Conclusions:Postoperative infection of gastric cancer causes an increase in CTC positive rate,peripheral blood CA135,CA199,CEA levels in patients after radical gastrectomy,which affects the patients'recovery of gastrointestinal function.
作者
文家治
向荣
Wen Jiazhi;Xiang Rong(Department of General Surgery,Chang'an Hospital in Xi'an,Xi'an 710018,China;Department of General Surgery,Hanzhong Traditional Chinese Medicine Hospital,Hanzhong 723100,China)
出处
《肿瘤研究与临床》
CAS
2024年第11期847-851,共5页
Cancer Research and Clinic
关键词
胃肿瘤
术后感染
循环肿瘤细胞
肿瘤标志物
胃功能
Gastric neoplasms
Postoperative infection
Circulating tumor cells
Tumor markers
Gastric function
