摘要
目的探究血清miR-135、miR-601、糖类抗原72-4(CA72-4)及糖类抗原19-9(CA19-9)的表达水平与胃癌(GC)诊断的相关性。方法选取2015年1月至2020年10月本院106例GC患者作为观察组,健康人群45例作为对照组,检测并比较两组血清miR-135、miR-601、CA72-4及CA19-9表达水平;Pearson相关系数分析各指标与GC发生相关性;受试者工作特征(ROC)曲线评价各指标对GC诊断效能。结果与对照组比较,观察组血清miR-135、miR-601、CA72-4及CA19-9表达水平升高差异有统计学意义(P<0.05);血清miR-135、miR-601、CA72-4及CA19-9与GC的发生呈正相关(P<0.05);血清miR-135、miR-601、CA72-4及CA19-9联合诊断GC灵敏度、特异性、准确度,阳性预测值、阴性预测值、ROC曲线下面积(area under curve,AUC)显著高于单一指标(P<0.05)。结果血清miR-135、miR-601、CA72-4及CA19-9的表达水平与GC的发生呈正相关。
Objective To explore the correlation between the expression levels of serum miR 135,miR-601,carbohydrate antigen 72-4(CA72-4)and carbohydrate antigen 19-9(CA19-9)and the diagnosis of gastric cancer(GC).Methods A total of 106 GC patients who were treated in our hospital from January 2015 to October 2020 were selected as the observation group,and 45 healthy people who underwent a physical examination in our hospital during the same period were selected as the control group to detect and compare the serum miR-135,miR-601,CA72-4 and CA19-9 expression levels;receiver operator characteristic(ROC)curve to evaluate the effects of serum miR-135,miR-601,CA72-4 and CA19-9 on GC Diagnostic power;Pearson correlation coefficient analysis of the correlation between serum miR-135,miR-601,CA72-4 and CA19-9 and the occurrence of GC.Results Compared with the control group,the serum miR-135,miR601,CA72-4 and CA19-9 expression levels in the observation group were significantly increased(P<0.05).Serum miR-135,miR-601,CA72-4 and CA19-9 were positively correlated with the occurrence of GC(P<0.05).The sensitivity,specificity,accuracy,positive predictive value,negative predictive value,and area under curve(AUC)of serum miR-135,miR-601,CA72-4 and CA19-9 in combined diagnosis of GC were significantly higher than single Indicator(P<0.05).Conclusion The expression levels of serum miR-135,miR601,CA72-4 and CA19-9 were positively correlated with the occurrence of GC,which has a high reference value for the clinical diagnosis of GC.
作者
杜记涛
曹建
赵稳
万相斌
李智
DU Jitao;CAO Jian;ZHAO Wen;WAN Xiangbin;LI Zhi(Department of General Surgery,Affiliated Cancer Hospital of Zhengzhou University/Henan Cancer Hospital,Zhengzhou,Henan,China,450003)
出处
《分子诊断与治疗杂志》
2021年第1期111-114,共4页
Journal of Molecular Diagnostics and Therapy
基金
河南省医学科技攻关计划省部共建项目(SB201901104)。
