摘要
目的 分析甲胎蛋白(AFP)、糖类抗原199(CA199)及癌胚抗原(CEA)在胃癌(GC)腹膜转移中的预测价值。方法 选取2019年8月至2022年5月于首都医科大学附属北京世纪坛医院接受治疗的GC患者97例作为观察组,将观察组分成无腹膜转移组(n=86)和有腹膜转移组(n=11),另选取同期在本院进行常规体检的健康人群89名为对照组,检测两组血清中AFP、CA199及CEA水平,并对其检测结果进行分析对比,评估AFP、CA199及CEA水平与GC临床特征之间的关系,评估AFP、CA199及CEA指标对于GC腹膜转移的预测效能,并使用Logistic回归分析GC腹膜转移患者预后的独立危险因素。结果 有腹膜转移组CA199、CEA水平均高于无腹膜转移组,差异具有统计学意义(P<0.05)。观察组AFP、CA199及CEA阳性检出率高于对照组,且CA199、CEA比较差异具有统计学意义(P<0.05);有腹膜转移组AFP、CA199及CEA阳性检出率高于对照组,且CA199、CEA比较差异具有统计学意义(P<0.05);GC组织中AFP、CA199阳性表达均与患者年龄相关(P<0.05);而GC组织中CEA与患者性别和年龄均相关(P<0.05)。AFP、CA199联合CEA指标对于GC腹膜转移的准确度、灵敏度、特异度、阳性预测值、阴性预测值均高于AFP、CA199及CEA单一预测(P<0.05);但AFP、CA199联合CEA指标预测效能与CA199联合CEA指标预测效能比较差异无统计学意义(P>0.05)。采用多因素Logistic回归分析结果显示,CAl99和CEA阳性为影响GC腹膜转移患者预后的独立危险因素(P<0.05)。结论 AFP、CA199及CEA联合检测能有效提高GC腹膜转移的预测效能,且CA199、CEA可作为评估GC腹膜转移患者预后的有效参考依据,值得临床推广应用。
Objective To investigate the predictive value of alpha fetoprotein(AFP),carbohydrate antigen199(CA199)and carcinoembryonic antigen(CEA)in peritoneal metastasis of gastric carcinoma(GC).Methods 97 patients with GC treated in Beijing Shijitan Hospital Affiliated to Capital Medical University from August 2019 to May 2022 were selected as the observation group,another 89 healthy people who un⁃derwent routine physical examination in our hospital during the same period were selected as the control group,the serum AFP,CA199 and CEA levels of the two groups were detected;the observation group was divided in⁃to two groups(n=86)without peritoneal metastasis and(n=11)with peritoneal metastasis,and the levels of AFP,CA199 and CEA in the serum of the two groups were detected,and the detection results were analyzed and compared,and the relationship between the levels of AFP,CA199 and CEA and clinical characteristics of GC was evaluated,the predictive efficacy of AFP,CA199 and CEA for GC peritoneal metastasis was evaluat⁃ed,and Logistic regression was used to analyze the independent risk factors for prognosis of GC peritoneal metastasis.Results The levels of CA199 and CEA in the peritoneal metastasis group were higher than those in the non⁃peritoneal metastasis group,and the differences were statistically significant(P<0.05).The positive detection rates of AFP,CA199 and CEA in the observation group were higher than those in the control group,and the differences in CA199 and CEA were statistically significant(P<0.05).The positive detection rates of AFP,CA199 and CEA in the peritoneal metastasis group were higher than those in the control group,and the differ⁃ences in CA199 and CEA were statistically significant(P<0.05).The positive expressions of AFP and CA199 in GC tissues were correlated with the age of patients(P<0.05);while CEA in GC tissues was correlated with gender and age(P<0.05).The accuracy,sensitivity,specificity,positive predictive value,and negative predictive value of AFP,CA199 combined with CEA indicator
作者
邵思论
翟玥
赵贺
SHAO Silun;ZHAI Yue;ZHAO He(Department of Laboratory Medicine,Beijing Shijitan Hospital,Capital Medical University,Beijing,China,100038;Cancer Nutrition and Metabolic Disease Center,Beijing Shijitan Hospital,Capital Medical University,Beijing,China,100038;Department of Gastrointestinal Tumor Surgery,Beijing Shijitan Hospital,Capital Medical University,Beijing,China,100038)
出处
《分子诊断与治疗杂志》
2023年第6期985-989,共5页
Journal of Molecular Diagnostics and Therapy
基金
北京市自然科学基金资助项目(7204251)。
