摘要
慢性疲劳综合征(chronic fatigue syndrome,CFS)作为发病率逐年增高、临床诊断易忽视、严重影响患者生活质量的疾病,阐明其发病机制,从病因学和症状学双面发力进行治疗,对于CFS患者的临床康复至关重要。限于其发病机制未明,针对病因治疗的方法有限,目前治疗方式主要集中在改善临床症状。在此背景下,建立良好的动物模型同时对动物模型进行有效评价尤为重要。本文综合CFS诊断标准和基础研究开展情况,总结近5年CFS基础研究中涉及的模型评价相关的行为学实验方法,首次从一般状态评价、疲劳状态评价、认知功能评价、情绪状态评价和疼痛程度评价5方面展开论述,旨在呈现现状、揭露问题、引发思考、推动改进。
The incidence of chronic fatigue syndrome(CFS)has gradually increased in recent years.Although CFS can severely affect patient quality of life,its clinical diagnosis is easily overlooked.Elucidating the pathogenesis of CFS and treating it from both etiological and symptomatological perspectives are crucial for patient recovery;however,its unclear pathogenesis means that etiological treatment options are limited,and current treatments mainly focus on improving clinical symptoms.In this context,there is a need to establish and evaluate a suitable animal model.This article comprehensively integrates the diagnostic criteria of CFS and progress in related basic research.We also summarize the behavioral experimental method used to evaluate CFS models in basic research in the past 5 years and discuss these evaluations from the perspectives of general condition,fatigue state,cognitive function,emotional state,and pain degree.This review aims to present the current situation,expose problems,trigger reflection,and promote improvements in the behavioral evaluation of animal models of CFS.
作者
屈媛媛
冯楚文
孙维伯
孙忠人
李彬彬
鲁菁
邵玉莹
郭述豪
陈涛
杨添淞
QU Yuanyuan;FENG Chuwen;SUN Weibo;SUN Zhongren;LI Binbin;LU Jing;SHAO Yuying;GUO Shuhao;CHEN Tao;YANG Tiansong(First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150040,China;Key Laboratory of Information Science of Traditional Chinese Medicine in Heilongjiang Province,Harbin 150040,China;Harbin Medical University Cancer Hospital,Harbin 150081,China;Second Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150001,China;the First Clinical Medical College of Heilongjiang University of Chinese Medicine,Harbin 150040,China;the Second Clinical Medical College of Heilongjiang University of Chinese Medicine,Harbin 150001,China)
出处
《中国实验动物学报》
CAS
CSCD
北大核心
2024年第11期1433-1444,共12页
Acta Laboratorium Animalis Scientia Sinica
基金
国家自然科学基金项目(82074539,82305394)
黑龙江省自然科学基金项目(YQ2023H019,LH2020H092)
教育部“春晖计划”合作科研项目(HZKY20220308-202201357)
黑龙江省中医药科研课题(ZHY2022-136)
中华中医药学会青年人才托举工程项目(CACM-2023-QNRC2-A04)
黑龙江省中医药学会2022-2024年度青年人才托举工程项目(2022-QNRC1-05)。
关键词
慢性疲劳综合征
动物模型
模型评价方法
行为学评价
chronic fatigue syndrome
animal model
model evaluation methods
behavioral evaluation
