摘要
动物模型是中医药基础研究的重要手段,气虚湿瘀是肾纤维化的主要证候。随着慢性肾病患病率及死亡率的逐年升高,气虚湿瘀型肾纤维化研究成为近年来的热点,亟须其病证结合动物模型的建立。本研究综述近年来相关造模方法,基于西医外科手术及化学因素建立肾纤维化病理模型,通过劳则气耗或饥则气损、内外湿相引加之客邪影响理论以及化学药物因素等从病因、病理角度建立气虚湿瘀病证结合模型,并从宏观表征、实验室指标、病理改变等角度制定气虚湿瘀型肾纤维化动物模型评价标准。将中医病证模型同现代科学相结合,构建相对完善的气虚湿瘀型肾纤维化动物模型造模方法及评价标准,为今后探究其发病机制及新的治疗思路提供模型支持,更有效地发挥中医药在肾纤维化中的治疗作用,推动中医药走向国际。
Animal models are important means for basic research in traditional Chinese medicine(TCM).Qi deficiency,dampness,and blood stasis are the main syndromes of renal fibrosis.With the increase in the morbidity and mortality of chronic kidney disease,study of renal fibrosis animal models of qi deficiency and dampness stasis syndrome has become a hotspot in recent years.Additionally,establishment of combined disease and syndrome animal models is urgently needed.This article reviews the recent modeling method that established the renal fibrosis pathological model based on western medicine surgery and chemical factors,and established the model of qi deficiency,dampness and blood stasis disease from the aspect of etiology and pathology through the theory of exhaustion leading to qi loss or hunger leading to qi loss,internal and external dampness combination,exogenous pathogenic factors,and chemical drugs.Additionally,these studies established the evaluation standard of the renal fibrosis animal model of qi deficiency,dampness and blood stasis type from the aspects of macroscopic characterization,laboratory indexes,and pathological changes.The TCM disease and syndrome model has been combined with modern science to establish a relatively perfect qi deficiency and dampness stasis kidney fibrosis animal model with evaluation criteria.Exploring its pathogenesis and new treatments supports the therapeutic role of TCM in kidney fibrosis and promotes TCM internationally.
作者
高冉冉
申振
连梦慧
韩聪
李伟
GAO Ranran;SHEN Zhen;LIAN Menghui;HAN Cong;LI Wei(College of Traditional Chinese Medicine,Shandong University of Traditional Chinese Medicine,Ji’nan 250014;China.2.First Clinical Medical School,Shandong University of Traditional Chinese Medicine,Ji’nan 250014;.3.Shandong University of Traditional Chinese Medicine,Ji’nan 250014;.4.Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Ji’nan 250014)
出处
《中国比较医学杂志》
CAS
北大核心
2023年第10期91-99,共9页
Chinese Journal of Comparative Medicine
基金
国家自然科学基金(82174179)
国家自然科学基金(82204886)
山东省自然科学基金(ZR2021LZY041)
山东省自然科学基金(ZR2022QH133)
中国博士后科学基金(2021M702039)
中国博士后科学基金(2023T160398)。
关键词
气虚湿瘀
肾纤维化
动物模型
模型评价方法
病证结合
qi deficiency and dampness stasis
kidney fibrosis
animal model
model evaluation method
