摘要
目的 分析布地奈德与沙丁胺醇治疗哮喘伴呼吸道病毒感染对肺功能的影响。方法 方便选取2022年5月—2024年5月于聊城市人民医院就诊的85例哮喘伴呼吸道病毒感染患儿为研究对象,根据不同治疗方法分为对照组(n=42)和研究组(n=43)。对照组应用沙丁胺醇治疗,研究组应用沙丁胺醇+布地奈德治疗。比较两组患儿症状缓解时间、炎性因子水平、免疫功能、肺功能。结果 治疗后,研究组的症状缓解时间短于对照组,差异有统计学意义(P<0.05)。治疗后,研究组的白细胞介素-6(interleukin-6,IL-6)、白细胞介素-8(interleukin-8,IL-8)、C反应蛋白(C-reactive protein,CRP)水平分别为(39.17±5.62)ng/L、(32.06±7.83)ng/L、(8.12±0.96)mg/L,低于对照组的(54.06±8.75)ng/L、(42.06±8.84)ng/L、(11.86±2.81)mg/L,差异有统计学意义(t=9.357,5.524,8.250;P均<0.05)。治疗后,研究组免疫球蛋白A、免疫球蛋白G、免疫球蛋白M、辅助性T淋巴细胞、辅助性T淋巴细胞/抑制/杀伤性T淋巴细胞水平均优于对照组,差异有统计学意义(P均<0.05)。治疗后,研究组动脉血氧分压、动脉血氧饱和度均高于对照组,动脉血二氧化碳分压低于对照组,差异有统计学意义(P均<0.05)。结论 哮喘伴呼吸道病毒感染患儿接受布地奈德与沙丁胺醇治疗,改善炎症、调节免疫功能,促进肺功能恢复,缩短症状缓解时间。
Objective To analyze the effect of budesonide and salbutamol on lung function in the treatment of asthma with respiratory virus infection.Methods A total of 85 children with asthma and respiratory virus infection who were treated in Liaocheng People's Hospital from May 2022 to May 2024 were conveniently selected as the study subjects.According to different treatment methods,they were divided into control group(n=42) and study group(n=43).The control group was treated with salbutamol,and the study group was treated with salbutamol + budesonide.The symptom relief time,inflammatory factor levels,immune function and lung function were compared between the two groups.Results After treatment,the symptom relief time of the study group was shorter than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of interleukin-6(IL-6),interleukin-8(IL-8)and C-reactive protein(CRP) in the study group were(39.17±5.62) ng/L,(32.06±7.83) ng/L and(8.12±0.96) mg/L,respectively,which were lower than(54.06±8.75) ng/L,(42.06±8.84) ng/L and(11.86±2.81) mg/L in the control group,and the differences were statistically significant(t=9.357,5.524,8.250;all P<0.05).After treatment,the levels of immunoglobulin A,immunoglobulin G,immunoglobulin M,cluster of differentiation 4 and cluster of differentiation 4/cluster of differentiation 8 in the study group were better than those in the control group,and the differences were statistically significant(all P<0.05).After treatment,the arterial partial pressure of oxygen and oxygen saturation in arterial blood in the study group were higher than those in the control group,and the arterial partial pressure of carbon dioxide was lower than that in the control group,the differences were statistically significant(all P<0.05).Conclusion Children with asthma and respiratory virus infection were treated with budesonide and salbutamol to improve inflammation,regulate immune function,promote lung function recovery,and shorten symptom relief time.
作者
李爽
杜腾越
赵自广
LI Shuang;DU Tengyue;ZHAO Ziguang(Department of pediatrics,Liaocheng People's Hospital,Liaocheng,Shandong,252000,China;Department of pediatrics,Liaocheng Veterans Hospital,Liaocheng,Shandong,252000,China)
出处
《中外医疗》
2024年第33期84-88,共5页
China & Foreign Medical Treatment
关键词
哮喘
患儿
呼吸道病毒感染
布地奈德
炎性因子
免疫功能
肺功能
Asthma
Children
Respiratory virus infection
Budesonide
Inflammatory factors
Immune function
Lung function
