摘要
目的探讨黄芪葛根汤结合胰激肽原酶肠溶片治疗早期糖尿病肾病的效果。方法选取2023年1—12月沂水县人民医院收治的80例早期糖尿病肾病患者为研究对象,根据不同的治疗方式分为研究组和对照组,每组40例。研究组在常规降糖治疗的基础上联合黄芪葛根汤和胰激肽原酶肠溶片治疗,对照组仅给予常规降糖治疗。比较两组生化指标、血液流变学指标、不良反应发生率。结果治疗后,两组生化指标较治疗前均有所改善,且研究组24 h尿蛋白排泄率、尿素氮水平均低于对照组,差异均有统计学意义(P均<0.05);两组血清肌酐水平比较,差异无统计学意义(P>0.05)。治疗后,两组血浆黏度较治疗前均有所降低,且研究组血浆黏度低于对照组,差异有统计学意义(P<0.05)。研究组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论黄芪葛根汤结合胰激肽原酶肠溶片治疗早期糖尿病肾病能够有效改善患者的临床症状,降低尿蛋白排泄率。
Objective Exploring the efficacy of Huangqi Gegen Decoction combined with pancreatic kininogenase enteric-coated tablets in the treatment of early diabetic nephropathy.Methods A total of 80 patients with early diabetic nephropathy admitted to Yishui People's Hospital from January to December 2023 were selected as the research objects.According to different treatment methods,they were divided into study group and control group,with 40 cases in each group.The study group was treated with Huangqi Gegen Decoction and pancreatic kininogenase enteric-coated tablets on the basis of routine hypoglycemic therapy,while the control group was only treated with routine hypoglycemic therapy.The biochemical indexes,hemorheology indexes and incidence of adverse reactions were compared between the two groups.Results After treatment,biochemical indexes of both groups were improved compared with before treatment,and 24 h urinary protein excretion rate and urea nitrogen level of the study group were lower than those of the control group,the differences were statistically significant(both P<0.05),and there was no significant difference in serum creatinine level between the two groups(P>0.05).After treatment,the plasma viscosity of both groups was decreased compared with before treatment,and the plasma viscosity of the study group was lower than that of the control group,the difference was statistically significant(P<0.05).The incidence of adverse reactions in the study group was lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion Huangqi Gegen Decoction combined with pancreatic kininogenase enteric-coated tablets in the treatment of early diabetic nephropathy can effectively improve the clinical symptoms of patients and reduce urinary protein excretion rate.
作者
魏丽娟
杨洪洪
WEI Lijuan;YANG Honghong(Department of Endocrinology,Yishui People's Hospital,Linyi 276400,Shandong,China)
出处
《糖尿病新世界》
2024年第20期168-171,共4页
Diabetes New World
关键词
黄芪葛根汤
胰激肽原酶肠溶片
早期糖尿病肾病
临床疗效
Huangqi Gegen Decoction
Pancreatic kininogenase enteric-coated tablets
Early diabetic nephropathy
Clinical effect
