摘要
目的探讨调肝汤加味联合雌孕激素序贯疗法对卵巢早衰(premature ovarian failure,POF)肾虚肝郁证患者的疗效以及对血清转化生长因子(transforming growth factor,TGF)-β1和白细胞介素(interleukin,IL)-21水平的影响。方法纳入2018年5月—2023年6月于该院就诊的POF肾虚肝郁证患者共计82例,根据随机数字表法分入两组,每组41例。对照组纳入患者采取雌孕激素序贯治疗;治疗组纳入患者给予的雌孕激素序贯的方法与时间同对照组,并采取调肝汤加味治疗。两组患者观察6周,经期停药。比较两组POF患者症状评分、肾虚肝郁证单项症状评分、治疗效果、血清性激素水平、血清TGF-β1和IL-21水平。结果3、6周后,两组POF患者Kupperman评分明显减少,同时治疗组分别减少更明显(P<0.05);6周后,两组患者肾虚肝郁证单项症状评分明显减少,同时治疗组减少更明显(P<0.05);6周后,治疗组病例总有效率为90.24%(37/41),显著高于对照组68.29%(28/41)(P<0.05);6周后,两组病例促卵泡生成激素(follicle-stimulating hormone,FSH)、促黄体生成激素(luteinizing hormone,LH)水平明显减少及雌二醇(estradiol,E_(2))水平明显增加,同时治疗组患者以上指标改善更优(P<0.05);6周后,两组血清TGF-β1水平明显增加及IL-21水平明显减少,同时治疗组患者以上指标改善更优(P<0.05)。结论调肝汤加味联合雌孕激素序贯疗法对POF肾虚肝郁证患者的临床疗效明显,有利于临床症状、肾虚肝郁证症状以及性激素水平的改善,以及调节血清TGF-β1和IL-21水平。
Objective To investigate the efficacy of Modified Tiaogan Decoction(调肝汤加味)and sequential therapy with estrogen treating premature ovarian failure(POF)of kidney deficiency and liver depression syndrome and its effect on serum levels of transforming growth factor(TGF)-β1 and interleukin(IL)-21.Methods A total of 82 POF cases with syndrome of kidney deficiency and liver depression treated in the hospital from May of 2018 to June of 2023 were included and divided into the two groups according to random number table method,41 cases in each group.The patients in the control group received sequential treatment with estrogen.The method and time of estrogen in the treatment group were the same as those in the control group,and Tiogan Decoction was added.Two groups were observed for 6 weeks,and the drug was stopped during menstruation.Symptom scores,single symptom scores of kidney deficiency and liver depression syndrome,therapeutic effect,serum sex hormone level,serum levels of TGF-β1 and IL-21 were compared between the two groups.Results After 3 and 6 weeks of treatment,the Kupperman score of POF cases in two groups was significantly reduced,and the decrease was more significant in the treatment group(P<0.05).After 6 weeks of treatment,the single symptom score of kidney deficiency and liver depression syndrome was significantly reduced in both groups,and the reduction was more obvious in the treatment group(P<0.05).After 6 weeks of treatment,the total effective rate of the treatment group was 90.24%(37/41),which was significantly higher than that of the control group(68.29%,28/41)(P<0.05).After 6 weeks of treatment,the levels of follicle-stimulating hormone(FSH)and luteinizing hormone(LH)decreased significantly and the levels of estradiol(E_(2))increased significantly in two groups,while the above indexes improved better in the treatment group(P<0.05).After 6 weeks of treatment,the serum levels of TGF-β1 and IL-21 were significantly increased in both groups,and the above indexes were better improved in the t
作者
郭瀚洲
吴献珍
GUO Hanzhou;WU Xianzhen(State Grid Corporation Occupational Disease Prevention and Treatment Institute,Jiande 311600,Zhejiang,China;Jiande Hospital of Traditional Chinese Medicine,Jiande 311600,Zhejiang,China)
出处
《辽宁中医杂志》
CAS
北大核心
2024年第12期132-135,共4页
Liaoning Journal of Traditional Chinese Medicine
关键词
调肝汤
卵巢早衰
转化生长因子-Β1
白细胞介素-21
肾虚肝郁证
Tiaogan Decoction(调肝汤)
premature ovarian failure
transforming growth factor-β1
interleukin-21
kidney deficiency and liver depression syndrome
