摘要
目的:探讨坤泰胶囊对卵巢早衰患者血清炎症指标、相关激素及血脂水平的影响。方法:选取90例卵巢早衰患者,依据随机数字表法分为对照组和观察组各45例。对照组给予戊酸雌二醇片治疗,观察组给予坤泰胶囊治疗,治疗周期为3个月,比较两组临床治疗效果。结果:治疗后,观察组总有效率(95.5%)高于对照组(82.2%)(P<0.05),两组血清白介素-21(IL-21)、肿瘤坏死因子-α(TNF-α)、卵泡刺激素(FSH)、促黄体生成素(LH)、低密度脂蛋白(LDL-C)均较治疗前下降,白介素-1β(IL-1β)、抗苗勒氏管激素(AM H)、雌二醇(E_2)、高密度脂蛋白(HDL-C)均较治疗前升高,且观察组IL-21、TNF-α、LDL-C水平较治疗组低,AM H、E_2、HDL-C水平较治疗组高(P<0.05), IL-1β、FSH和E_2水平两组比较未见差异(P>0.05)。结论:坤泰胶囊治疗卵巢早衰疗效显著,对患者炎症因子、相关激素和血脂水平均有改善。
Objective:To explore the influence of Kuntai capsule on serum levels of inflammation cytokines,sex hormone,and blood lipid of patients with premature ovarian failure.Methods:A total of 90 patients with premature ovarian failure were selected,and they were randomly divided into control group and observation group.The patients in control group were treated by pentanoic acid estradiol tablets for 3 months,and the patients in observation group were treated by Kuntai capsule for 3 months.The therapeutic effect was compared between the two groups.Results:After treatment,the effective rate of patients in observation group was 95.5%,which was significant higher than that(82.2%)of patients in control group(P<0.05).The serum levels of IL-21,TNF-α,FSH,LH,and LDL-C of patients in both groups had decreased significantly after treatment(P<0.05),but the levels of serum IL-1β,AMH,E2,HDL-C had were increased significantly(P<0.05).The levels of IL-21,TNF-α,LDL-C of patients in treatment group were significant lower than those of women in control group(P<0.05),but the levels of AMH,E2,HDL-C of patients in treatment group were significant higher than those of women in control group(P<0.05).The levels of IL-1β,FSH and E2 had no significant different between the two groups(P>0.05).Conclusion:Kuntai capsule used to treat patients with premature ovarian failure has significant curative effect,which can improve the levels of inflammatory cytokines,sex hormones,and blood lipid of patients,so it is value to be popularized clinically.
作者
刁瑞英
蔡学泳
甘辉梅
陈蕾
田芙颖
镇万华
易庭华
DIAO Ruiying;CAI Xueyong;GAN Huimei;CHEN Lei;TIAN Fuying;ZHEN Wanhua;YI Tinghua(The Second Hospital of Shenzhen,Guangdong Province,518035)
出处
《中国计划生育学杂志》
2019年第3期308-311,共4页
Chinese Journal of Family Planning
关键词
卵巢早衰
坤泰胶囊
炎症因子
性激素
血脂
Premature ovarian failure
Kuntai capsule
Inflammatory cytokines
Sex hormones
Blood lipid
