摘要
目的观察地衣芽孢杆菌在降低血液透析患者血清硫酸吲哚酚(IS)、硫酸对甲酚(PCS)、氧化三甲胺(TMAO)中的作用。方法选择2019年4月-2021年3月武汉科技大学附属普仁医院收治的血液透析患者70例,采用随机数字表法分为观察组35例和对照组35例。对照组维持血液透析治疗,透析频率每周3次,单次透析时间4 h。观察组采用血液透析联合地衣芽孢杆菌治疗,血液透析方案与对照组一致,口服地衣芽孢杆菌活菌胶囊,0.50 g/次,3次/d。2组患者均维持治疗2个月。比较2组患者的血清IS、PCS、TMAO、肌酐、尿素氮、大肠埃希菌、粪肠球菌、双歧杆菌、乳酸杆菌、过氧化脂质(LPO)、超氧化物歧化酶(SOD)水平,以及心血管疾病的发病率和药物不良反应的发生情况。结果治疗后,观察组和对照组的IS分别为(22.32±3.96)mg/L、(25.31±4.05)mg/L;PCS分别为(15.21±2.35)mg/L、(22.84±3.17)mg/L;TMAO分别为(4.02±0.81)μmol/L、(8.74±2.13)μmol/L;肌酐分别为(1162.53±267.08)μmol/L、(1168.92±358.72)μmol/L;尿素氮分别为(32.01±4.64)mmol/L、(32.58±4.73)mmol/L;大肠杆菌分别为(6.52±1.25)CFU/g、(7.52±1.34)CFU/g;粪肠球菌分别为(5.64±0.61)CFU/g/、(7.53±0.92)CFU/g;双歧杆菌分别为(3.21±0.79)CFU/g、(2.61±0.85)CFU/g;乳酸杆菌分别为(3.26±0.63)CFU/g、(2.79±0.68)CFU/g;LPO分别为(6.42±1.28)mol/L、(7.51±1.96)mol/L;SOD分别为(27.19±6.04)U/mL、(24.07±4.69)U/mL;2组比较差异有统计学意义(P<0.05)。观察组和对照组的不良反应发生率比较差异无统计学意义(P>0.05)。观察组和对照组的心血管疾病发病率分别为0.00%(0/35)和17.14%(6/35),观察组心血管疾病发病率低于对照组(P<0.05)。结论地衣芽孢杆菌应用于血液透析患者的治疗中,有助于减少血清IS、PCS、TMAO的累积,调节肠道菌群状态,降低心血管疾病发病风险。
Objective This study aims to explore the effect of Bacillus licheniformis in reducing serum levels of indoxyl sulfate(IS),p-cresyl sulfate(PCS),and trimethylamine N-Oxide(TMAO)in hemodialysis patients.Methods Seventy blood dialysis patients admitted to Wuchang University of Science and Technology Affiliated Puren Hospital from April 2019 to March 2021 were randomly divided into an observation group of 35 cases and a control group of 35 cases.The control group received regular blood dialysis treatment three times a week,with each session lasting 4 hours.The observation group received blood dialysis combined with Bacillus licheniformis treatment,following the same dialysis schedule as the con trol group.Bacillus licheniformis live capsules were administered orally at a dose of 0.50 g per time,three times a day.Both groups underwent treatment for 2 months.A comparison was made between the two groups in terms of serum levels of IS,PCS,TMAO,creatinine,blood urea nitrogen,Escherichia coli,Enterococcus,Bifidobacterium,Lactobacillus,lipid peroxidation(LPO),superoxide dismutase(SOD),as well as the incidence of cardiovascular diseases and drug adverse reactions.Results After treatment,the IS levels in the observation group and control group were(22.32±3.96)mg/L and(25.31±4.05)mg/L,respectively;PCS levels were(15.21±2.35)mg/L and(22.84±3.17)mg/L,respectively;TMAO levels were(4.02±0.81)μmol/L and(8.74±2.13)μmol/L,respectively;creatinine levels were(1162.53±267.08)μmol/L and(1168.92±358.72)μmol/L,respectively;blood urea nitrogen levels were(32.01±4.64)mmol/L and(32.58±4.73)mmol/L,respectively;Escherichia coli levels were(6.52±1.25)CFU/g and(7.52±1.34)CFU/g,respectively;Enterococcus levels were(5.64±0.61)CFU/g and(7.53±0.92)CFU/g,respectively;Bifidobacterium levels were(3.21±0.79)CFU/g and(2.61±0.85)CFU/g,respectively;Lactobacillus levels were(3.26±0.63)CFU/g and(2.79±0.68)CFU/g,respectively;LPO levels were(6.42±1.28)mol/L and(7.51±1.96)mol/L,respectively;SOD levels were(27.19±6.04)U/mL and(24.07±4.69
作者
于洋
卢文君
刘凌汐
崔学彬
戚婷
唐小铁
YU Yang;LU Wenjun;LIU Lingxi;CUI Xuebin;QI Ting;TANG Xiaotie(Department of Nephrology,Puren Hospital Affiliated to Wuhan University of Science and Technology,Wuhan 430080,Hubei,China;Department of Cardiovascular Medicine,95829 Military Hospital of the Chinese People's Liberation Army,Wuhan 430012,Hubei,China)
出处
《医学研究与战创伤救治》
CAS
北大核心
2024年第10期1045-1049,共5页
Journal of Medical Research & Combat Trauma Care
基金
湖北省卫生计生委科研项目(WJ2018H0107)
武汉市卫生健康委员会项目(WX21D37)。
关键词
血液透析
硫酸吲哚酚
硫酸对甲酚
氧化三甲胺
地衣芽孢杆菌
hemodialysis
indoxyl sulfate
p-cresyl sulfate
trimethylamine N-oxide
Bacillus licheniformis
