摘要
目的观察中药熏洗联合有氧运动治疗类风湿关节炎(RA)的临床疗效。方法选取2022年3月至2023年4月新疆医科大学第一附属医院中医综合科收治的RA患者96例,按照随机数字表法分为治疗组和对照组,每组48例。对照组采用甲氨蝶呤片治疗,治疗组在对照组基础上加中药熏洗联合有氧运动治疗,2组均治疗4周。比较2组治疗前及治疗1、2、4周28个关节疾病活动度-红细胞沉降率评分系统(DAS28-ESR)评分变化。比较2组治疗前后C反应蛋白(CRP)、类风湿因子(RF)、白细胞介素17(IL-17)、ESR、辅助性T细胞17(Th17)、调节性T细胞(Treg)、Th17/Treg水平及类风湿关节炎患者报告的临床结局(PRO)量表评分变化。结果治疗1、2、4周,2组DAS28-ESR评分均较本组治疗前下降(P<0.05),且治疗组均低于对照组同期(P<0.05)。治疗后,2组血清RF、ESR、CRP、IL-17水平均较本组治疗前降低(P<0.05),且治疗组均低于对照组(P<0.05)。治疗后,2组Th17/Treg、Th17均较本组治疗前降低(P<0.05),Treg均较本组治疗前升高(P<0.05),且治疗组Th17/Treg、Th17均低于对照组(P<0.05),Treg高于对照组(P<0.05)。治疗后,2组PRO量表各维度评分均较本组治疗前升高(P<0.05),且治疗组均高于对照组(P<0.05)。治疗组总有效率87.50%(42/48),对照组总有效率60.42%(29/48),治疗组总有效率高于对照组(P<0.05)。结论中药熏洗联合有氧运动可有效缓解RA患者临床症状,抑制炎症,提高其生活质量。
Objective To observe the clinical efficacy of herbal fumigation combined with aerobic exercise for rheumatoid arthritis(RA).Methods A total of 96 RA patients treated in Department of Integrated Traditional Chinese Medicine,the First Affiliated Hospital of Xinjiang Medical University from March 2022 to April 2023 were randomly assigned into treatment group(n=48)and control group(n=48).All patients were managed by methotrexate,and those in treatment group were additionally treated with herbal fumigation combined with aerobic exercise.Treated for 4 weeks,the aim was to compare Disease Activity Score in 28 joints-Erythrocyte Sedimentation Rate(DAS28-ESR)on day 0,and at weeks 1,2,4,C-reactive protein(CRP),rheumatoid factor(RF),interleukin 17(IL-17),T helper 17(Th17)cells,regulatory t cells(Treg),Th17/Treg,patient-reported outcomes(PRO)in patients with RA.Results At weeks 1,2 and 4,DAS28-ESR scores in the two groups were significantly decreased than before treatment(P<0.05),the decrease in the treatment group was more prevalent than the control group(P<0.05).After treatment,the levels of RF,ESR,CRP,IL-17 in the two groups were significantly decreased(P<0.05),which were significantly lower in the treatment group than in the control group(P<0.05).After treatment,significantly decreased Th17/Treg and Th17,and increased Treg were found in the two groups(all P<0.05),and the treatment group was superior to the control group for Th17/Treg,Th17,Treg(all P<0.05).The dimension score of PRO in the two groups was significantly increased(P<0.05),the increase in the treatment group was more common than the control group(P<0.05).The overall effective rate in the treatment group was significantly higher than that in the control group(87.50%[42/48]vs 60.42%[29/48],P<0.05).Conclusion For RA patients,herbal fumigation combined with aerobic exercise can effectively relieve clinical symptoms,inhibit inflammation and improve quality of life.
作者
姚玉红
苏丹
陈金荣
YAO Yuhong;SU Dan;CHEN Jinrong(Department of Integrated Traditional Chinese Medicine,the First Affiliated Hospital of Xinjiang Medical University,Urumqi,Xinjiang 830000)
出处
《河北中医》
2024年第12期1986-1989,1995,共5页
Hebei Journal of Traditional Chinese Medicine
基金
新疆护理学会2022年度立项科研课题(编号:2022XH13)。
关键词
类风湿关节炎
温针疗法
熏洗疗法
有氧运动
Rheumatoid arthritis
Needle warming therapy
Fumigation therapy
Aerobic exercise
