摘要
中药治疗疾病已有数千年的历史,在现代疾病治疗中依然占据着不可替代的位置。中药的成分复杂,作用方式具有多途径、多靶点的特点,致使中药的药理作用及其机制复杂。中药的作用原理和作用机制一直是各界学者关注探讨的热点问题。越来越多的研究表明,间接调控作用(indirect action)在中药的作用模式中占据重要地位。肠道菌群被认为是一种新的无形代谢器官,中药能够基于器官之间的联系,通过靶向作用于肠道菌群跨器官发挥间接作用以治疗疾病。为此,该文从中医藏象学说与现代医学研究的器官轴出发,基于肠道以及肠道菌群与肝、脑、肾、肺等靶器官的对话交流机制,对中药的间接调控作用机制进行综述,以期为间接作用型中药的作用机制研究及创新药物研发提供借鉴。
Traditional Chinese medicine(TCM)has been treating diseases for thousands of years and still holds an irreplaceable position in modern disease treatment.The composition of TCM is complex,and its mode of action features multi-pathway and multi-target characteristics,making its pharmacological actions and mechanisms complicated.The principles and mechanisms of TCM have always been a hot topic among scholars from various fields.Increasingly,studies show that indirect action plays an important role in the mode of action of TCM.The gut microbiota is regarded as a new invisible metabolic organ,and TCM can treat diseases by targeting the gut microbiota,thereby exerting an indirect effect across organs based on the connection between organs.Therefore,this paper summarized the indirect regulatory mechanisms of TCM based on the visceral manifestation theory and the organ axis of modern medical research.It also discussed the talks and communication mechanisms between the gut microbiota and target organs such as the liver,brain,kidney,and lungs,providing references for research on the mechanisms of indirect action of TCM and the development of innovative drugs.
作者
翟玉静
王晓萱
王雪
窦亚洁
许妍妍
李遇伯
ZHAI Yu-jing;WANG Xiao-xuan;WANG Xue;DOU Ya-je;XU Yan-yan;LI Yu-bo(School of Chinese Materia Medica,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2024年第22期5977-5987,共11页
China Journal of Chinese Materia Medica
基金
国家自然科学基金项目(81873194,82004093)
国家中医药管理局青年岐黄学者支持项目
天津市科技局重大专项与工程计划项目(21ZXJBSY00040)。
关键词
中药
藏象学说
器官对话
间接调控作用
肠道菌群
作用机制
traditional Chinese medicine
visceral manifestation theory
organ talks
indirect action
gut microbiota
mechanism
