摘要
目的:观察中西医结合治疗小儿抗生素相关性腹泻(脾胃虚弱型)的临床疗效及安全性。方法:选取2018年12月—2020年1月我院诊治的84例抗生素相关性腹泻患儿作为研究对象,按随机数表法分为观察组(42例)和对照组(42例)。两组均停用一切抗生素,对照组仅予布拉氏酵母菌散口服治疗,观察组在对照组的基础上联用参术止泻方口服治疗。两组均治疗7 d。比较两组临床症状恢复进程(腹泻停止时间、大便正常时间)、血清胃泌素降低情况、临床疗效及不良反应发生情况。结果:观察组与对照组的总有效率分别为95.2%(40/42)、81.0%(34/42),观察组的腹泻停止时间、大便正常时间均显著低于对照组,差异均有统计学意义(P<0.05),两组治疗后的GAS含量较治疗前相比均有明显改善,且观察组的改善程度更优于对照组,差异均有统计学意义(P<0.05)。两组均未发生不良反应。结论:中西医结合治疗小儿抗生素相关性腹泻(脾胃虚弱型)疗效确切,可明显改善临床症状,降低血清胃泌素的分泌,促进病情恢复,临床应用价值大。
Objective:To observe the clinical efficacy and safety of integrated traditional Chinese and western medicine in the treatment of infantile antibiotic-associated diarrhea(weakness of spleen and stomach).Methods:84 children with antibiotic-associated diarrhea diag-nosed and treated in our hospital from December 2018 to January 2020 were randomly divided into observation group(n=42)and control group(n=42).All antibiotics were stopped in both groups,while those in the control group were only given oral treatment with Brasella powder,while those in the observation group were treated with Shenzhu Zhixie prescription on the basis of the control group.Both groups were treated for 7 days.The recovery process of clinical symptoms(diarrhea stopping time,stool normal time),the decrease of serum gas-trin,clinical efficacy and adverse reactions were compared between the two groups.The total effective rates of the observation group and the control group were 95.2%(40/42)and 81.0%(34/42),respectively.The diarrhea stopping time and normal stool time of the observa-tion group were significantly lower than those of the control group,and the difference was statistically significant(P<0.05).The GAS content of the two groups after treatment was significantly improved compared with that before treatment,and the degree of improvement of the observation group was better than that of the control group.The differences were statistically significant(P<0.05).There were no adverse reactions in both groups.Conclusion:The combination of traditional Chinese and western medicine is effective in the treatment of infantile antibiotic-associated diarrhea(weakness of spleen and stomach).It can obviously improve the clinical symptoms,reduce the secretion of serum gastrin and promote the recovery of the disease.
作者
木金雪
王学玲
缪青芳
靳千城
耿少怡
MU Jin-xue;WANG Xue-ling;MIAO Qing-fang;JIN Qian-cheng;GENG Shao-yi(Affiliated Hospital of Hebei College of traditional Chinese Medicine,Shijiazhuang 050011,China)
出处
《内蒙古中医药》
2022年第6期50-53,共4页
Inner Mongolia Journal of Traditional Chinese Medicine
关键词
参术止泻方
抗生素相关性腹泻
布拉氏酵母菌散
中西医结合治疗
Shenzhu Zhixie recipe
Antibiotic associated diarrhea
Brachii yeast powder
Integrated traditional Chinese and western medicine treatment
