摘要
目的观察扶正安中汤联合卡培他滨对气阴两虚型三阴性乳腺癌(TNBC)术后患者的治疗效果。方法选择2022年8月至2023年8月在广东省第二中医院接受治疗的60例气阴两虚型TNBC术后患者作为研究对象,随机分为观察组和对照组,每组30例。对照组给予卡培他滨治疗,观察组在对照组的基础上加用扶正安中汤治疗,疗程为4周。观察2组患者治疗前后中医证候积分、血清肿瘤标志物及白细胞计数(WBC)、血小板计数(PLT)、血红蛋白(HGB)水平的变化情况,并评价2组患者的临床疗效与治疗安全性。结果(1)治疗后,观察组的中医证候积分较治疗前明显降低(P<0.05),对照组的中医证候积分有降低趋势,但差异无统计学意义(P>0.05);治疗后组间比较,观察组的中医证候积分明显低于对照组(P<0.05)。(2)治疗后,2组患者的血清肿瘤标志物癌胚抗原(CEA)、糖蛋白125(CA125)、糖蛋白153(CA153)水平均较治疗前明显降低(P<0.05),且观察组的CEA、CA125、CA153水平明显低于对照组(P<0.05)。(3)治疗后,对照组的WBC、HGB、PLT水平均较治疗前明显降低(P<0.05),观察组的WBC、HGB、PLT水平有降低趋势,但差异均无统计学意义(P>0.05);治疗后组间比较,观察组的WBC、HGB、PLT水平高于对照组(P<0.05)。(4)观察组的总有效率为90.00%(27/30),明显高于对照组的33.33%(10/30)(P<0.05);观察组的不良反应发生率(16.67%)明显低于对照组(43.33%)(P<0.05)。结论扶正安中汤联合卡培他滨治疗能够提高气阴两虚型TNBC术后患者的临床疗效,有效改善患者的临床症状,降低肿瘤标志物水平,减轻化疗药物毒副作用,安全性较高。
Objective To observe the therapeutic effect of Fuzheng Anzhong Decoction combined with capecitabine on postoperative patients with triple-negative breast cancer(TNBC)of qi-yin deficiency type.Methods A total of 60 TNBC postoperative patients with qi-yin deficiency type,who received treatment in Guangdong Second of Traditional Chinese Medicine Hospital from August 2022 to August 2023,were selected as the study objects and randomly divided into observation group and control group,with 30 cases in each group.The control group was treated with capecitabine,and the observation group was treated with Fuzheng Anzhong Decoction on the basis of treatment for the control group.The courses of treatment covered four weeks.The changes of traditional Chinese medicine(TCM)syndrome scores,serum levels of tumor markers,white blood cell(WBC)count,platelet(PLT)count and hemoglobin(HGB)level of the two groups were observed.The clinical efficacy and safety of the two groups were evaluated.Results(1)After treatment,the TCM syndrome score of the observation group was significantly lower than that before treatment(P<0.05),while the TCM syndrome score of the control group showed a decreasing trend,but the difference was not statistically significant(P>0.05).The TCM syndrome score of the observation group was significantly lower than that of the control group by the comparison between two groups after treatment(P<0.05).(2)After treatment,the levels of serum tumor markers,namely carcinoembryonic antigen(CEA),glycoprotein 125(CA125),and glycoprotein 153(CA153)in both groups were significantly lower than those before treatment(P<0.05),and the levels of CEA,CA125,and CA153 in the observation group were significantly lower than those in the control group(P<0.05).(3)After treatment,the levels of WBC,HGB,and PLT in the control group were significantly decreased compared with those before treatment(P<0.05),whereas the levels of WBC,HGB,and PLT in the observation group demonstrated a downward tendency,but without statistical significance(P>0.05).A
作者
杨惠娜
付亚斐
吴玢
李雪真
郭智涛
YANG Huina;FU Yafei;WU Bin;LI Xuezhen;GUO Zhitao(The Fifth Clinical Medical School of Guangzhou University of Chinese Medicine,Guangzhou 510405 Guangdong,China;Guangdong Second Traditional Chinese Medicine Hospital,Guangzhou 510095 Guangdong,China)
出处
《中药新药与临床药理》
CAS
CSCD
北大核心
2024年第12期1907-1911,共5页
Traditional Chinese Drug Research and Clinical Pharmacology
基金
广东省中医药局科研项目(202205042033413760)。
关键词
三阴性乳腺癌
气阴两虚
扶正安中汤
卡培他滨
化疗
肿瘤标志物
预后
triple-negative breast cancer
deficiency of qi and yin
Fuzheng Anzhong Decoction
capecitabine
chemotherapy
tumor markers
prognosis
