摘要
目的评估胸部低剂量螺旋CT与7种自身抗体联合应用在肺癌早期筛查中的价值。方法本研究纳入2021年6月至2023年6月于河南省肿瘤医院健康管理中心体检的152例疑似肺癌患者,所有研究对象接受胸部低剂量螺旋CT检查,其中147例接受肺癌7种自身抗体检测。以病理检查结果为金标准,分析胸部低剂量螺旋CT、肺癌自身抗体检测单独及联合筛查的灵敏度、特异度,及3种筛查方式对肺癌的早期筛查价值。结果根据病理诊断结果,152例疑似肺癌患者中确诊肺癌138例,肺部良性病变14例。胸部低剂量螺旋CT单独用于肺癌早期筛查具有较高的灵敏度(0.919)和特异度(0.862),但准确率(0.783)和阴性预测值(0.194)相对较低。而肺癌自身抗体单独筛查的灵敏度范围为0.639~0.848,特异度范围为0.638~0.836,准确率范围为0.609~0.801,阳性预测值范围为0.162~0.434,阴性预测值范围为0.101~0.126。将胸部低剂量螺旋CT与肺癌自身抗体联合应用后,灵敏度为0.923,特异度为0.882,准确率为0.901,阳性预测值为0.984,阴性预测值为0.483,均高于单独筛查。结论联合应用胸部低剂量螺旋CT和肺癌自身抗体在肺癌早期筛查中表现出更高的诊断性能,特别是在提高灵敏度、特异度和准确率方面明显优于单独应用。
Objective To evaluate the value of low-dose spiral CT combined with seven autoantibodies in early screening of lung cancer.Methods A total of 152 suspected lung cancer patients were examined in the Health Management Center of Henan Cancer Hospital from June 2021 to June 2023.All the study subjects underwent low-dose spiral CT of the chest,among which 147 patients were tested for autoantibodies of lung cancer.Taking the results of pathological examination as the gold standard,the sensitivity and specificity of chest low-dose spiral CT and lung cancer,and the early screening value of three screening methods for lung cancer were analyzed.Results According to the pathological diagnosis results,out of 152 suspected lung cancer patients,138 were diagnosed with lung cancer and 14 had benign lung lesions.Chest low-dose spiral CT alone for early screening of lung cancer has a high sensitivity(0.919)and specificity(0.862),but a relatively low accuracy(0.783)and negative predictive value(0.194).However,the sensitivity of the seven autoantibodies screened for lung cancer alone ranged from 0.639 to 0.848,the specificity ranged from 0.638 to 0.836,the accuracy range ranged from 0.609 to 0.801,the positive predictive value ranged from 0.162 to 0.434,and the negative predictive value ranged from 0.101 to 0.126.However,after the combination of chest low-dose thoracic spiral CT with seven autoantibodies of lung cancer,the diagnostic index was significantly improved,with sensitivity of 0.923,specificity of 0.882,accuracy of 0.901,positive predictive value of 0.984 and negative predictive value of 0.483,all of which were higher than the screening alone.Conclusion The combined application of low-dose spiral CT and lung cancer autoantibodies shows higher diagnostic performance in early screening of lung cancer,especially in improving sensitivity,specificity,and accuracy,which is significantly better than using them alone.
作者
王彪
董亚锋
马雯
WANG Biao;DONG Yafeng;MA Wen(Medical Imaging Department,the Affiliated Cancer Hospital of Zhengzhou University/Henan Cancer Hospital,Zhengzhou 450008,China;Health Management Center,the Affiliated Cancer Hospital of Zhengzhou University/Henan Cancer Hospital,Zhengzhou 450008,China)
出处
《河南医学研究》
CAS
2024年第23期4278-4282,共5页
Henan Medical Research
