摘要
目的 探讨中性粒细胞与淋巴细胞比值(Neutrophil to lymphocyte ratio, NLR)与儿童特异性皮炎(Atopic Dermatitis, AD)的相关性。方法 回顾性分析2021年1月-2023年6月在本院就诊的90例AD患儿(AD组)和体检中心40名健康儿童(对照组)的临床资料,其中AD组根据SCORAD评分分为轻度AD组(≤15分)和中、重度AD组(>15分)。检测并比较AD组患儿和对照组血常规相关参数、hs-CRP、ESR和总IgE水平的差异,探讨轻度AD组和中、重度AD组患儿NLR数值的差异,两种指标的相关性分析采用Pearson分析,AD患儿NLR数值的影响因素采用Logistic回归分析,利用受试者操作特征(Receiver Operating Characteristic, ROC)曲线探讨NLR数值在诊断中、重度AD中的临床效能。结果 与对照组相比,AD组患儿WBC、N、EOS、NLR、hs-CRP和总IgE水平明显升高,差异均具有统计学意义(P<0.05);AD患儿EOS、NLR数值、总IgE与SCORAD评分呈现正相关性(P<0.05),相关系数分别为0.543、0.661和0.295。轻度和中、重度AD患儿NLR数值分别为(2.28±0.16)和(2.97±0.25),与轻度AD患儿相比,中、重度AD患儿NLR数值明显升高,差异均具有统计学意义(t=15.945,P<0.05)。SCORAD评分(OR=10.444)、EOS(OR=6.501)和血清总IgE(OR=4.369)是AD患儿NLR数值升高的危险因素。ROC曲线结果发现,NLR数值诊断中、重度AD的临床效能显著,AUC为0.945(95%CI:0.891~0.999),当NLR数值的截断值为2.88,诊断敏感度和特异度分别为91.62%和90.53%。结论 AD患儿NLR数值显著升高,EOS、总IgE及SCORAD评分升高是AD患儿NLR数值的重要影响因素,NLR可作为诊断中、重度AD的一项生物学标志物。
Objective To investigate the correlation between the neutrophil to lymphocyte ratio(NLR)and pediatric atopic dermatitis(AD).Methods Retrospective analysis was conducted on the clinical data of 90 children with AD(AD group)and 40 healthy children(control group)who visited our hospital from January 2021 to June 2023.The AD group was categorized into mild AD group(≤15 points)and moderate-to-severe AD group(>15 points)based on SCORAD scores.Differences in blood routine parameters,hs-CRP,ESR,and total IgE levels between the AD and control groups were detected and compared.The NLR values between mild and moderate-to-severe AD groups were also compared.Pearson's analysis was utilized for correlation analysis,and logistic regression analysis was applied to identify factors influencing NLR values in children with AD.The receiver operating characteristic(ROC)curve was employed to assess the clinical efficacy of NLR values in diagnosing moderate-to-severe AD.Results Compared to the control group,the WBC,N,EOS,NLR,hs-CRP,and total IgE levels in the AD group were significantly elevated,with statistically significant differences(all P<0.05).EOS,NLR values,and total IgE showed a positive correlation with SCORAD scores(P<0.05),with correlation coefficients of 0.543,0.661,and 0.295,respectively.The NLR values in moderate-to-severe AD children were significantly higher than in mild AD children,with a statistically significant difference(t=15.945,P<0.05).SCORAD scores(OR=10.444),EOS(OR=6.501),and serum total IgE(OR=4.369)were identified as risk factors for elevated NLR values in children with AD.The AUC for NLR values in diagnosing moderate-to-severe AD was 0.945(95%CI:0.891~0.999),with a sensitivity and specificity of 91.62%and 90.53%,respectively,when the cut-off value was 2.88.Conclusions NLR values are significantly increased in children with AD,and elevated EOS,total IgE,and SCORAD scores are significant factors affecting NLR values in these children.NLR can serve as a biological marker for diagnosing moderate-to-severe AD.
作者
贾妮旦
袁涛
程彩虹
江佳慧
卢晓红
Jia Nidan;Yuan Tao;Cheng Caihong;Jiang Jiahui;Lu Xiaohong(Department of Pediatrics,the First Affiliated Hospital of Wannan Medical College(Yijishan Hospital),Wuhu,Anhui 241004,China;Department of Dermatology,the First Affiliated Hospital of Wannan Medical College(Yijishan Hospital),Wuhu,Anhui 241004,China)
出处
《齐齐哈尔医学院学报》
2024年第23期2214-2218,共5页
Journal of Qiqihar Medical University
基金
2023年安徽省自然科学基金青年基金(2308085QH269)
安徽省高校自然科学重点研究项目(2023AH051781)。
