摘要
目的探讨联合外用解毒活血方和生长因子对早期糖尿病足(DF)患者创面修复的影响。方法选取2022年1月至2024年1月于重庆中医药学院附属第一医院就诊的128例早期DF(Wagner分级1~2级)患者为研究对象,随机分为对照组(C组)、中药外洗组(ZY组)、生长因子组(SZ组)和中药外洗+生长因子组(ZYSZ组),每组各32例,4组患者均予以基础治疗及每天使用相应方法换药处理。比较不同处理方式的4组患者临床疗效、疗效指数、创面愈合时间、踝臂指数(ABI)、趾臂指数(TBI)、炎症因子水平[C反应蛋白(CRP)、降钙素原(PCT)、血沉(ESR)]及不良反应。结果4组患者基线水平一致(P>0.05);治疗后,4组患者总有效率比较差异有统计学意义(P<0.05),两两比较显示,ZYSZ组总有效率明显高于C组(P<0.05);C组、ZY组、SZ组、ZYSZ组疗效指数依次升高(P<0.05),而创面愈合时间依次减少(P<0.05);ZYSZ组ABI和TBI水平均明显高于C组和ZY组(P<0.05),SZ组TBI高于C组(P<0.05);与治疗前相比,各组治疗后的CRP、PCT及ESR水平均明显降低(P<0.05),而治疗后方差分析显示,4组间CRP、PCT及ESR水平比较差异有统计学意义(P<0.05),进一步事后两两比较,ZY组和SZ组比较差异无统计学意义(P>0.05),其余各组两两比较差异有统计学意义(P<0.05);各组间总不良反应发生率比较差异无统计学意义(P>0.05)。结论联合外用解毒活血方和生长因子防治早期DF具有较好的临床疗效,能提高疗效指数,缩短创面愈合时间,提高ABI和TBI水平,降低炎症因子水平,安全性较好,为早期DF中西医结合防治提供了新的外治方法。
Objective To explore the effect of combination of external Jiedu Huoxue prescription and growth factor on wound repair in patients with early diabetic foot(DF).Methods A total of 128 patients with early DF(Wagner classification 1-2)treated in the First Affiliated Hospital of Chongqing College of Traditional Chinese Medicine from January 2022 to January 2024 were selected as the study subjects.They were randomly divided into control group(group C),Chinese medicine external washing group(group ZY),growth factor group(group SZ)and Chinese medicine external washing+growth factor group(group ZYSZ),with 32 patients in each group.Basic treatment and corresponding dressing change were performed in each group every day.The clinical efficacy,efficacy index,wound healing time,ankle-brachial index(ABI),toe-brachial index(TBI),levels of inflammatory factors[C-reactive protein(CRP),procalcitonin(PCT),erythrocyte sedimentation rate(ESR)]and incidence of adverse reactions were compared among the four groups.Results There was no significant difference in the baseline information among the 4 groups(P>0.05).After treatment,there were significant differences in the total effective rate among the 4 groups(P<0.05).The total effective rate in group ZYSZ was significantly higher than that in group C(P<0.05).The efficacy index in group C,group ZY,group SZ and group ZYSZ increased successively(P<0.05),while the wound healing time decreased successively(P<0.05).ABI and TBI levels in group ZYSZ were significantly higher than those in group C and group ZY(P<0.05),The TBI level in group SZ was higher than that in group C(P<0.05).After treatment,the levels of CRP,PCT and ESR significantly decreased in all groups(P<0.05).Analysis of variance showed that there were significant differences in CRP,PCT and ESR levels among the four groups(P<0.05).Further pairwise comparison among the four groups showed that there was no significant difference in CRP,PCT and ESR levels between group ZY and group SZ(P>0.05),while there were significant differences in
作者
李勇
杨孛
朱丹平
崔世奎
吴锦林
Li Yong;Yang Bei;Zhu Danping;Cui Shikui;Wu Jinlin(Department of Endocrinology and Metabolism,The First Affiliated Hospital,Chongqing College of Traditional Chinese Medicine,Chongqing 400021,China)
出处
《成都医学院学报》
CAS
2024年第6期1028-1032,共5页
Journal of Chengdu Medical College
基金
重庆市卫生健康委员会和科学技术局联合医学科研项目(No:2022MSXM158)
重庆市科研机构绩效激励引导专项项目(No:jxyn2021-1-18)。
关键词
解毒活血方
生长因子
糖尿病足
Jiedu Huoxue prescription
Growth factor
Diabetic foot
