摘要
目的报告中国恶性肿瘤患者肌肉减少症的流行病学调查结果。方法纳入中国肿瘤营养队列研究常见恶性肿瘤营养状态与临床结局相关性研究(INSCOC)数据库2013年7月至2023年12月86家三级甲等医院19种恶性肿瘤患者61627例。采用亚洲肌肉减少症工作组(AWGS)2019年肌肉减少症诊断标准诊断肿瘤患者肌肉减少症。χ2检验或Fisher确切概率法分析比较不同特征肿瘤患者肌肉减少症患病情况。结果肿瘤患者中肌肉减少症的患病率为18.1%(11175/61627)。肌肉减少症患病率因肿瘤类型、TNM分期、年龄、性别、地理区域及治疗情况不同而存在差异:消化系统肿瘤患者肌肉减少症患病率较高,其中胰腺癌患者患病率最高[32.4%(311/961)];肌肉减少症患病率随TNM分期增高而增大(P<0.05);70岁以上患者肌肉减少症患病率最高[34.7%(3510/10129)];女性肿瘤患者肌肉减少症患病率高于男性患者[16.1%(5544/34381)比20.7%(5631/27246),P<0.05];东北地区的患者患病率最低[14.7%(2398/16300)],接受手术治疗的患者患病率最高[22.1%(1635/7412)]。此外,在某些肿瘤类型中,不同医疗保险类型、职业、教育水平、民族、居住地的患者肌肉减少症患病率存在显著性差异,文化水平低、农民患者发生肌肉减少症的风险更高。结论本研究首次以大规模数据报告了肿瘤患者肌肉减少症的患病率,消化道系统、老年、农民、低教育水平及进展期肿瘤患者等是发生肌肉减少症的高风险人群。
Objective This study aims to investigate the prevalence of sarcopenia specifically in Chinese patients with malignant tumors.Method A total of 61627 patients with 19 types of malignant tumors from 86 grade-A hospitals from July 2013 to December 2023 were included in the INSCOC database of the Chinese Tumor Nutrition Cohort Study.The diagnostic criteria for sarcopenia provided by the Asian W orking Group on Sarcopenia(AWGS)in 2019 were used.Chi-square test or Fisher exact test was used to compare the prevalence of sarcopenia in patients with different population characteristics.Result The prevalence of sarcopenia in cancer patients was 18.1%.The prevalence of sarcopenia varied with tumor type,TNM stage,age,gender,administrative area and treatment.The prevalence of sarcopenia was higher in patients with digestive system cancers,and the highest prevalence was found in patients with pancreatic cancer[32.4%(311/961)].The prevalence of sarcopenia increased with the increase of TNM stage(P<0.05).The prevalence of sarcopenia was the highest in patients over 70 years old[34.7%(3510/10129)].The prevalence of sarcopenia in female cancer patients was higher than that in male patients[16.1%(5544/34381)us 20.7%(5631/27246),P<0.05].The lowest prevalence was found in the Northeast region[14.7%(2398/16300)].Patients who received surgical treatment had the highest prevalence[22.1%(1635/7412)].In addition,in some tumor types,there were significant differences in the prevalence of sarcopenia among patients with different medical insurance types,occupation,education level,ethnicity,and place of residence.Patients with low education level and farmers had a higher risk of sarcopenia.Conclusion This study is the first to report the incidence of sarcopenia in tumor patients on a large scale,with a prevalence of 18%.Patients with digestive system cancers,elderly,farmers,low education level and advanced tumor are high risk groups for sarcopenia.
作者
宋春花
程好晴
崔久嵬
许红霞
王昆华
翁敏
郭增清
周福祥
林源
巴一
袁凯涛
胡雯
马虎
李苏宜
冯长艳
李增宁
赵青川
李纪鹏
郑瑾
吕全军
李涛
陈俊强
贺英
高茜
吴静
王辉
姚庆华
杨家君
刘明
宋新霞
陈公琰
丛明华
马文君
余亚英
罗素霞
周岚
乔秋阁
王巍
冯永东
罗琪
邱红
施咏梅
姜海平
齐玉梅
管文贤
陈甲信
黄河
余震
方玉
陈子华
付振明
王畅
李薇
石汉平
Song Chunhua;Cheng Haoqing;Cui Jiuwei;Xu Hongxia;Wang Kunhua;Weng Min;Guo Zengqing;Zhou Fuxiang;Lin Yuan;Ba Yi;Yuan Kaitao;Hu Wen;Ma Hu;Li Suyi;Feng Changyan;Li Zengning;Zhao Qingchuan;Li Jipeng;Zheng Jin;Lu Quanjun;Li Tao;Chen Junqiang;He Ying;Gao Qian;Wu Jing;Wang Hui;Yao Qinghua;Yang JiaJun;Liu Ming;Song Xinxia;Chen Gongyan;Cong Minghua;Ma Wenjun;Yu Yaying;Luo Suxia;Zhou Lan;Qiao Qiuge;Wang Wei;Feng Yongdong;Luo Qi;Qiu Hong;Shi Yongmei;Jiang Haiping;Qi Yumei;Guan Wenxian;Chen Jiaxin;Huang He;Yu Zhen;Fang Yu;Chen Zihua;Fu Zhenming;Wang Chang;Li Wei;Shi Hanping(Department of Epidemiology,School of Public Health,Zhengzhou University,Zhengzhou 450001,Henan,China;Cancer Center,the First Bethune Hospital of Jjilin University,Changchun 130021,Jilin,China;Department of Clinical Nutrition,Daping Hospital,Army Medical University,Chongqing 400000,China;Department of Clinical Nutrition,the First Affiliated Hospital of Kunming Medical University,Kunming 650032,Yunnan,China;Department of Medical Oncology,Fuyjian Cancer Hospital,Fyjian Medical University,Fuzhou 350014,Fujian,China;Department of Chemoradiotherapy,Zhongnan Hospital of Wuhan University,Wuhan 430071,Hubei,China;Department of Gastrointestinal Surgery,Affiliated Tumor Hospital of Guangxi Medical University,Nanning 530021,Guangxi,China;Cancer Medicine Center,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences,Bejing 100730;Department of General Surgery,the First Afiliated Hospital of Sun Yat-sen University,Guangzhou 510080,Guangdong,China;Department of Clinical Nutrition,West China Hospital,Chengdu 610041,Sichuan,China;Department of Oncology,the Second Afiliated Hospital of Zunyi Medical University,Zunyi 563000,Guizhou,China;Department of Oncology,Nutrition and Metabolism,Anhui Provincial Hospital Affiliated to Anhui Medical University/Anhui Provincial Cancer Hospital,Hefei 230031,Anhui,China;Department of Clinical Nutrition,Chongqing Cancer Hospital,Chongqing 40000,China;Department of Clinical Nutrition,the First Hospital of Hebei Medical Uni
出处
《肿瘤代谢与营养电子杂志》
2024年第5期638-650,共13页
Electronic Journal of Metabolism and Nutrition of Cancer
基金
国家重点研发计划项目(2022YFC2009600)。
关键词
恶性肿瘤
肌肉减少症
四肢骨骼肌指数
现况调查
患病率
影响因素
老年
消化道系统
Malignant tumor
Sarcopenia
Appendicular skeletal muscle mass index
Current investigation
Prevalence
Influencing factors
Aged
Digestive system
