摘要
目的探究寻常型银屑病患者血清白介素-26(IL-26)、外周血辅助性T细胞17/调节性T细胞(Th17/Treg)水平,并分析临床检测意义。方法本研究为回顾性研究。选取2020年12月至2023年12月安康市中医医院收治的寻常型银屑病患者100例,其中男56例、女44例,年龄(38.65±6.25)岁。并按2∶1比例选取安康市中医医院同期收治的慢性皮肤病患者50例、体检健康者(对照组)50例进行对照研究,慢性皮肤病组中男27例、女23例,年龄(38.85±6.15)岁;对照组中男28例、女22例,年龄(38.44±6.18)岁。分析各组性别、年龄等基线资料及IL-26、Th17/Treg差异,通过二元logistic回归分析寻常型银屑病的影响因素,通过受试者操作特征曲线(ROC)分析IL-26、Th17/Treg水平诊断寻常型银屑病的效能,并分析银屑病皮损面积和严重程度指数(PASI)与IL-26、Th17/Treg的关系。采用χ^(2)检验、t检验、方差分析进行统计比较。结果3组性别、年龄、体重指数、吸烟率、饮酒率比较,差异均无统计学意义(均P>0.05)。寻常型银屑病组与慢性皮肤病组患者病程差异无统计学意义(P>0.05)。寻常银屑病组IL-26、Th17、Treg、Th17/Treg分别为(641.82±192.05)ng/L、(5.36±1.34)%、(3.09±0.91)%、1.83±0.55,慢性皮肤病组分别为(571.15±155.31)ng/L、(4.58±1.06)%、(3.81±1.19)%、1.28±0.38,对照组分别为(504.46±122.51)ng/L、(3.93±0.88)%、(5.14±1.51)%、0.81±0.24,3组上述指标比较,差异均有统计学意义(F=11.535、26.054、52.482、90.638,均P<0.05)。二元logistic回归分析结果显示,IL-26、Th17/Treg均是寻常型银屑病的危险因素(均P<0.05)。ROC分析结果显示,IL-26、Th17/Treg诊断寻常型银屑病曲线下面积(AUC)分别为0.700、0.891。将IL-26、Th17/Treg纳入回归方程,得出模型数据,结果显示诊断寻常型银屑病的AUC为0.912,灵敏度0.920,特异度为0.790。线性回归结果显示,IL-26、Th17、Treg、Th17/Treg均与寻常型银屑病患者PASI显著相�
Objective To investigate the levels of serum interleukin-26(IL-26)and peripheral blood helper T cell 17/regulatory T cells(Th17/Treg)in patients with psoriasis vulgaris,and analyze the clinical significance of detection.Methods A total of 100 patients with psoriasis vulgaris admitted to Ankang Hospital of Traditional Chinese Medicine from December 2020 to December 2023 were retrospectively selected,and 50 cases of chronic skin diseases and 50 healthy subjects(control group)admitted to Ankang Hospital of Traditional Chinese Medicine during the same period were selected in the ratio of 2:1 for a control study.The differences in baseline data such as gender and age as well as levels of IL-26 and Th17/Treg among the groups were analyzed.The influencing factors of psoriasis vulgaris were analyzed by binary logistic regression analysis,and the diagnostic efficacies of IL-26 and Th17/Treg levels in psoriasis vulgaris were analyzed by the receiver operating characteristic curve(ROC).The relationships between Psoriasis Area and Severity Index(PASI)score and levels of IL-26 and Th17/Treg were analyzed.χ^(2) test,t test,and variance analysis were used.Results There was no statistically significant difference in the gender,age,body mass index,smoking rate,or drinking rate among the three groups(all P>0.05).There was no statistically significant difference in the course of disease between the psoriasis vulgaris group and chronic skin disease group(P>0.05).The levels of IL-26,Th17,Treg,and Th17/Treg were(641.82±192.05)ng/L,(5.36±1.34)%,(3.09±0.91)%,and 1.83±0.55 in the psoriasis vulgaris group,(571.15±155.31)ng/L,(4.58±1.06)%,(3.81±1.19)%,and 1.28±0.38 in the chronic skin disease group,(504.46±122.51)ng/L,(3.93±0.88)%,(5.14±1.51)%,and 0.81±0.24 in the control group,with statistically significant differences(F=11.535,26.054,52.482,and 90.638,all P<0.05).Binary logistic regression analysis showed that both IL-26 and Th17/Treg levels were risk factors for psoriasis vulgaris(both P<0.05).ROC analysis showed that the a
作者
罗茜
闫亮
邓柳红
Luo Xi;Yan Liang;Deng Liuhong(Department of Dermatology,Ankang Hospital of Traditional Chinese Medicine,Ankang 725000,China;Department of Dermatology,Xi'an Red Cross Hospital,Xi'an 710054,China;Department of Dermatology,Ankang People's Hospital,Ankang 725000,China)
出处
《国际医药卫生导报》
2024年第24期4191-4196,共6页
International Medicine and Health Guidance News
基金
陕西省科学技术研究发展计划(S2018YFSF010628)。
