摘要
目的:探讨针药结合助卵养巢法治疗肾虚血瘀型卵巢储备功能减退的临床疗效。方法:将60例肾虚血瘀型卵巢储备功能减退患者随机分为观察组和对照组,每组30例。观察组接受针药结合助卵养巢法治疗,对照组接受西药人工周期法治疗。两组均治疗3个疗程。比较两组患者治疗前后中医证候积分、血清性激素水平、抗苗勒氏管激素(Anti Miillerian Hormone,AMH)水平及双侧窦卵泡数(Antral Follicle Count,AFC),比较两组综合治疗疗效及不良反应发生情况。结果:经过治疗,两患者中医证候积分均较治疗前显著降低(P<0.01),且观察组在降低中医证候积分方面较对照组更优(P<0.05);治疗后两组患者的血清性激素卵泡刺激素(Follicle-Stimulating Hormone,FSH)、促黄体生成素(Luteinizing Hormone,LH)和FSH/LH水平均显著降低(P<0.01),血清雌二醇(Estradiol,E2)水平均显著升高(P<0.01),组间差异无统计学意义(P>0.05);治疗后,两组患者的血清AMH水平和AFC值均显著增加(P<0.01),且观察组在提高AMH水平和AFC值方面均明显优于对照组(P<0.05,P<0.01);观察组的总有效率高于对照组,但差异无统计学意义(P>0.05);观察组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论:针药结合助卵养巢法能有效治疗肾虚血瘀型卵巢储备功能减退,在提高AMH、增加AFC方面表现出更佳的效果,且无不良反应,值得临床推广使用。
Objective:To explore the clinical effect of acupuncture and medicine plus nourishing ovary method on the renal deficiency and blood stasis type of decreased ovarian reserve function.Methods:A total of 60 patients with the renal deficiency and blood stasis type of decreased ovarian reserve function were randomly divided into the observation group and the control group,with 30 cases in each group.The observation group was treated by acupuncture and medicine plus nourishing ovary method,and the control group was treated by Western medicine artificial menstrual cycle method.The patients in both groups were treated for 3 courses.Results:After treatment,the TCM syndrome scores in the observation group and the control group were significantly lower than before treatment(P<0.01),and the observation group was better than the control group in reducing syndrome scores(P<0.05).After treatment,the levels of serum sex hormones FSH,LH and FSH/LH were significantly decreased in both groups(P<0.01),serum E2 level in both groups were significantly increased(P<0.01),but there was no statistical significance between the groups(P>0.05).After treatment,the serum AMH level and AFC value in the two groups were significantly increased(P<0.01),and the observation group was significantly better than the control group in improving AMH level and AFC value(P<0.05,P<0.01).The total efficiency in the observation group was higher than that in the control group,but the difference was not statistically significant(P>0.05).The incidence of adverse reactions in the observation group was lower than the control group,and the difference was statistically significant(P<0.05).Conclusion:Acupuncture and medicine plus nourishing ovary method can effectively treat the renal deficiency and blood stasis type of decreased ovarian reserve function,and show a better effect in enhancing AMH and AFC without adverse reactions,which is worthy of clinical promotion and application.
出处
《中医临床研究》
2024年第29期23-28,共6页
Clinical Journal Of Chinese Medicine
基金
湖南省卫生健康委科研项目(C202305019294,202205034625)
湖南省“十四五”第一批中医药领军人才和学科带头人培养项目
湖南省中医药科研计划课题(A2024036,C2022012)
深圳市“医疗卫生三名工程”项目(SZZYSM202311019)
国家中医药管理局“尤昭玲全国名中医传承工作室”建设项目(国中医药办人教函[2022]75号)。
关键词
卵巢储备功能减退
肾虚血瘀型
针药结合
性激素
窦卵泡数
Decreased ovarian reserve function
The kidney deficiency and blood stasis type
Acupuncture and medicine combination
Sex hormone
Antral follicle count
