摘要
目的:探讨卵巢储备功能下降的病机。方法:通过对2004年3月至2015年3月中医药治疗卵巢储备功能下降的临床研究文献进行分析,得出卵巢储备功能下降的用药规律及其证候分布,从而探讨卵巢储备功能下降的病机特点。根据纳入和排除标准筛选出50篇符合要求的文献进行统计分析。结果:1)证候分布:在相关的50篇文章中,常见证候频次从高到低依次为肾虚血瘀证、肝肾阴虚证、肾虚肝郁证、脾肾阳虚证、心肾不交证、痰湿内阻证。证素分布依次为:肾虚证、阴虚证、血瘀证、气滞证、血热证、脾气虚、气虚证、血虚证、痰湿证、血寒证。2)总体用药规律:用药频次前3名的中药分别为熟地黄、菟丝子、枸杞子;药物类别由高到低前3位为:补虚药(55.76%)、活血化瘀药(20.08%)、理气药(4.55%)。结论:肾虚是卵巢储备功能下降的主要病机,血瘀是本病的一个重要病机环节,气血两虚可能是另一个重要机制,肝郁在发病过程中有重要作用。
Objective： To discuss the pathogenesis of diminished ovarian reserve（DOC）. Methods： By analyzing the literature on clinical research of treating DOC with traditional Chinese medicine published from March, 2004 to March, 2015, the medication rules of DOC and the syndrome distribution were obtained, therefore, to explore its pathogenesis. According to inclusion and exclusion criteria, 50 papers were included in the statistic analysis. Results：1） Syndromes distribution： According to descending order of the frequency in the related 50 papers, common syndromes were kidney deficiency and blood stasis syndrome, liver-kidney yin-deficiency syndrome,kidney deficiency and liver depression syndrome, spleen-kidney yang-deficiency syndrome,syndrone disharmony between heart and kidney phlegm-dampness intemal accunulation syndrome.While syndrome elements were kidney deficiency syndrome,Yin deficiency syndrome, blood stasis syndrome, Qi stagnation syndrome, blood heat syndrome, spleen-Qi deficiency syndrome, Qi deficiency syndrome, blood deficiency syndrome, phlegm and dampness syndrome, and blood cold syndrome in descending order of distribution. 2） General medication rule： The top three drugs were Shu Di Huang（radix rehmanniae praeparata）, Tu Si Zi（semen cuscutae）, Gou Qi Zi（fructus lycii）. The top three drug categories were tonics（55.76%）, blood-activating and stasis-resolving medicine（20.08%） and Qi regulating herbs（4.55%）. Conclusion： Kidney deficiency is the major pathogenesis of DOC, and blood stasis is an essential aspect of the pathogenesis, Qi and blood deficiency could be another main mechanism. Furthermore, liver depression plays an important role in the attack of the disease.
出处
《西部中医药》
2016年第6期53-56,共4页
Western Journal of Traditional Chinese Medicine
关键词
卵巢储备功能下降
病机
文献分析
diminished ovarian reserve
the pathogenesis
literature analysis
