摘要
目的:分析液基薄层细胞学检查(TCT)阴性且高危型人乳头瘤病毒(hrHPV)阳性患者宫颈病理结果。方法:收集2019年1月—2022年3月于扬州大学附属苏北人民医院行宫颈癌筛查,结果为TCT阴性且hrHPV阳性,同时行阴道镜下组织病理学检查患者的临床资料。分析单一及多重hrHPV在不同宫颈病变患者中感染情况,单一hrHPV感染患者人乳头瘤病毒(HPV)型别及病理结果。结果:多重hrHPV感染的高级别鳞状上皮内病变(HSIL)和宫颈癌(统称HSIL+)患病率(21.82%)高于单一hrHPV感染(16.74%),差异有统计学意义(P<0.05)。单一感染中HPV16、31、39、58、52的HSIL+检出率分别为25.51%[OR=3.47,95%CI(1.29,9.32)]、28.89%[OR=2.07,95%CI(1.54,7.92)]、23.08%[OR=1.86,95%CI(1.45,6.38)]、22.66%[OR=2.26,95%CI(1.76,6.75)]、21.32%[OR=2.11,95%CI(1.59,4.80)],高于HPV18。结论:对于TCT阴性患者,除HPV16、18阳性需转诊阴道镜外,HPV31、39、58、52及多重hrHPV阳性的患者也应引起注意,必要时采取积极的干预措施,避免遗漏宫颈肿瘤。
Objective To analyze the cervical pathological results of patients with negative liquid-based thin-layer cytology test(TCT)and positive high-risk human papillomavirus(hrHPV).Methods From January 2019 to March 2022,cervical cancer screening was performed in North Jiangsu People's Hospital Affiliated to Yangzhou University.The results were TCT negative and hrHPV positive,and the clinical data of patients who underwent histopathological examination under colposcope were collected.The infection of single and multiple hrHPV in patients with different cervical lesions,the type of human papillomavirus(HPV)and pathological results in patients with single hrHPV infection were analyzed.Results The prevalence of high-grade squamous intraepithelial lesion(HSIL)and cervical cancer(referred to as HSIL+)in multiple hrHPV infection(21.82%)was higher than that in single hrHPV infection(16.74%),and the difference was statistically significant(P<0.05).The HSIL+detection rates of HPV16,31,39,58,52 in a single hrHPV infection were 25.51%[OR=3.47,95%CI(1.29,9.32)],28.89%[OR=2.07,95%CI(1.54,7.92)],23.08%[OR=1.86,95%CI(1.45,6.38)],22.66%[OR=2.26,95%CI(1.76,6.75)],21.32%[OR=2.11,95%CI(1.59,4.80)],higher than HPV18.Conclusions For TCT negative patients,in addition to HPV16,18 positive patients who need to be referred to colposcopy,HPV31,39,58,52 and multiple hrHPV positive patients should also be paid attention,and take active action if necessary to avoid missing cervical tumors.
作者
王倩
练慧斌
卢丹
WANG Qian;LIAN Huibin;LU Dan(Department of Obstetrics and Gynecology,North Jiangsu People's Hospital Affiliated to Yangzhou University,Yangzhou,Jiangsu 225001,China;Department of Burns and Plastic Surgery,North Jiangsu People's Hospital Affiliated to Yangzhou University,Yangzhou,Jiangsu 225001,China)
出处
《医药前沿》
2024年第34期10-13,共4页
Journal of Frontiers of Medicine
基金
国家自然科学基金面上项目(82072088)。
关键词
人乳头瘤病毒
液基薄层细胞学检查
宫颈上皮内瘤变
子宫颈肿瘤
Human papilloma virus
Thin-prep cytology test
Cervical squamous intraepithelial lesion
Uterine cervical neoplasms
