摘要
目的探讨推拿联合龙胆泻肝汤对肝火扰心型不寐症的治疗价值。方法纳入河南推拿职业学院附属医院2020年1月至2023年1月收治的肝火扰心型不寐症患者106例,按随机数字表法分成对照组与治疗组,各53例。对照组采用龙胆泻肝汤治疗,治疗组采用扶阳论治引阳入阴推拿手法联合龙胆泻肝汤治疗。比较两组中医疗效及匹兹堡睡眠质量指数(PSQI)评分,分别在治疗前后检测并比较血清去甲肾上腺素(NE)、谷氨酸(Glu)、γ-氨基丁酸(GABA)、5-羟色胺(5-HT)、褪黑素(MT)水平,记录两组不良反应情况。结果治疗组(94.34%)总有效率较对照组(81.13%)高(P<0.05)。治疗后,两组PSQI评分、NE水平下降,Glu、GABA、5-HT、MT水平上升,与治疗前和对照组对比,治疗组变化幅度较大(P<0.05)。两组不良反应差异无统计学意义(P>0.05)。结论扶阳论治引阳入阴推拿手法联合龙胆泻肝汤能进一步提高肝火扰心型不寐症患者的中医疗效,降低PSQI评分,作用机制可能与其对神经递质的调节作用有关,安全性高。
Objective To explore the therapeutic value of massage combined with Longdan Xiegan Decoction on heart-type insomnia caused by liver fire.Methods A total of 106 patients with liver fire disturbed cardiotype insomnia admitted to President of the Affiliated Hospital of Henan Vocational College of Massage from January 2020 to January 2023,and divided into treatment group(53 cases)and control group(53 cases)according to random number table method.The control group was treated with Longdan Xiegan Decoction,and the treatment group was treated with Fuyang theory and Yin manipulation combined with Longdan Xiegan Decoction.The Chinese medicine efficacy efficacy and Pittsburgh sleep quality index(PSQI)score were compared between the two groups.Serum levels of norepinephrine(NE),glutamic acid(Glu),γ-aminobutyric acid(GABA),5-hydroxytryptamine(5-HT)and melatonin(MT)were detected and compared,and the adverse reactions of the two groups were recorded.Results The total effective rate of treatment group(94.34%)was higher than that of control group(81.13%)(P<0.05).After treatment,PSQI scores and NE levels decreased,while Glu,GABA,5-HT and MT levels increased in both groups.Compared with before treatment and control group,the changes in the treatment group were greater(P<0.05).There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion Fuyang Treatment combined with Gentian Xiegan Decoction can further improve the efficacy of traditional Chinese medicine and reduce the score of PSQI in patients with heart-type insomnia caused by liver fire.The mechanism of action may be related to the regulation of neurotransmitters,and the overall safety is high.
作者
马新
刘国宝
周勇浩
马磊
MA Xin;LIU Guobao;ZHOU Yonghao;MA Lei(Department of Traditional Chinese Medicine,Henan Vocational College of Massage’Luoyang 471023,China;the Affiliated Hospital of Henan Vocational College of Massage,Luoyang 471023,China)
出处
《河南医学研究》
CAS
2024年第22期4175-4179,共5页
Henan Medical Research
关键词
肝火扰心型
不寐症
龙胆泻肝汤
liver fire disturbing heart type
insomnia
Longdan Xiegan Decoction
