摘要
Hedgehog(Hh)信号通路具有改善胚胎发生和维持组织稳态等功能,通过发挥影响肿瘤微环境、干预细胞凋亡、调节血管生成等机制,对多种肿瘤疾病的发生、发展及恢复起关键作用。故靶向抑制Hh信号通路异常激活,已成为缓解与治疗癌症的潜在研究策略。目前,中医药治疗癌症等疑难重症,因不良反应小、有效率高、无依赖性、标本兼治等优势,备受青睐。该文通过总结综述Hh信号通路与肿瘤的关联性以及中医药干预Hh信号通路发挥抗肿瘤作用的可行性,旨在为中医药防治癌症提供科学理论和研究思路。
The Hedgehog(Hh)signaling pathway has the functions of improving embryogenesis and maintaining tissue homeostasis.By influencing the tumor microenvironment,intervening in cell apoptosis,and regulating angiogenesis,it is pivotal in the occurrence,progression,and recovery of various tumors.Therefore,targeting and inhibiting the abnormal activation of the Hh pathway has become a potential research strategy for alleviating and treating cancer.Currently,traditional Chinese medicine(TCM)is highly favored for treating cancer and other challenging and severe diseases due to its advantages,such as minimal side effects,high efficacy,lack of dependency,and the ability to address both symptoms and underlying causes.This review aimed to provide a scientific foundation and research ideas for the prevention and treatment of cancer with TCM by summarizing and reviewing the correlation between the Hh pathway and tumors,as well as the feasibility of using TCM to modulate the Hh pathway for anti-tumor effects.
作者
王家兴
史奇
张作良
武权生
WANG Jia-xing;SHI Qi;ZHANG Zuo-liang;WU Quan-sheng(Clinical College of Chinese Medicine,Gansu University of Chinese Medicine,Lanzhou 730000,China;Affiliated Hospital,Gansu University of Chinese Medicine,Lanzhou 730000,China;College of Pharmacy,Gansu University of Chinese Medicine,Lanzhou 730000,China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2024年第21期5771-5796,共26页
China Journal of Chinese Materia Medica
基金
国家自然科学基金项目(82260949)。
