摘要
目的分析急性缺血性脑卒中(AIS)病人的全身免疫炎症指数(SII)和全身炎症反应指数(SIRI)与AIS病人神经损伤程度及神经功能预后的相关性。方法选取2021年12月至2022年6月徐州医科大学附属医院急诊科或神经内科收治的230例AIS病人作为AIS组和150例同期体检人群作为对照组,采血检测血常规,分别收集其血小板、中性粒细胞、单核细胞、淋巴细胞计数,计算SII、SIRI。记录AIS病人入院时美国国立卫生研究院卒中量表(NIHSS)评分以及发病90 d后的改良Rankin量表(mRS)评分。按NIHSS评分将病人分为轻度、中度、重度组,比较三组病人的SII、SIRI是否有差别。按mRS评分将病人分为预后良好与预后不良组,比较两组病人的SII、SIRI是否有差别。之后,按照SII和SIRI的水平高低进行分组,比较两组之间的NIHSS评分和mRS评分是否有差别。结果AIS组病人的SII[523.08(350.24,768.74)×10^(9)/L比373.58(285.90,507.04)×10^(9)/L]和SIRI[1.11(0.71,1.68)×10^(9)/L比0.58(0.40,0.82)×10^(9)/L]均较对照组显著升高(P<0.05)。且AIS组中,重度组SII和SIRI较中度组显著升高(P<0.05),中度组的SII和SIRI较轻度组显著升高(P<0.05)。90 d后随访,预后不良的AIS病人SII和SIRI均显著高于预后良好的AIS病人(P<0.05)。高SII组病人的NIHSS评分[8.00(4.00,20.25)分比3.00(2.00,5.00)分]和mRS评分[3.00(1.00,4.75)分比1.00(0,1.00)分]较低SII组显著升高(P<0.05)。同样,高SIRI组病人的NIHSS评分[8.50(6.00,21.00)分比3.00(2.00,5.00)分]和mRS评分[3.00(1.00,5.00)分比1.00(0,1.25)分]较低SIRI组显著升高(P<0.05)。结论AIS病人的SII和SIRI均显著升高,且SII和SIRI水平越高,卒中病人神经损伤越重,神经功能预后越不良;提示SII和SIRI可评估AIS病人病情严重程度及神经功能预后。SII、SIRI可能成为提示AIS病情严重程度及预后的新指标。
Objective To analyze the correlation of systemic immune inflammatory index(SII)and systemic inflammatory response index(SIRI)with the degree of neurological injury and prognosis in patients with acute ischemic stroke(AIS).Methods Totally 230 AIS patients,who were admitted to the Emergency Department or Neurology Department of the Affiliated Hospital of Xuzhou Medical University from December 2021 to June 2022,were chosen as AIS group,and 150 simultaneous physical examination population as control group.Blood was collected and tested for the counts of platelets,neutrophils,lymphocytes and monocytes and SII and SIRI were calculated.The National Institutes of Health Stroke Scale(NIHSS)score at admission and the modified Rankin Scale(mRS)score at three months after onset of AIS were recorded.The patients were assigned into light,moderate and serious groups according to NIHSS score,and the differences in SII and SIRI among the three groups were compared.The patients were assigned into good prognosis group and poor prognosis group according to mRS score,and the differences in SII and SIRI between the two groups were compared.Then the patients were assigned into groups according to the levels of SII and SIRI,and the differences in the NIHSS score and mRS score were compared between the two groups.Results Levels of SII[523.08(350.24,768.74)×10^(9)/L vs.373.58(285.90,507.04)×10^(9)/L]and SIRI[1.11(0.71,1.68)×10^(9)/L vs.0.58(0.40,0.82)×10^(9)/L]in AIS group were significantly higher than those in control group(P<0.05).In the AIS group,The SII and SIRI levels of severe group were significantly higher than those of moderate group(P<0.05),and SII and SIRI levels in moderate group were significantly higher than those in mild group(P<0.05).After 90 days of follow-up,SII and SIRI levels of AIS patients with poor prognosis were significantly higher than those of AIS patients with good prognosis(P<0.05).The NIHSS scores[8.00(4.00,20.25)points vs.3.00(2.00,5.00)points]and mRS scores[3.00(1.00,4.75)points vs.1.00(0,1.00)points]
作者
伏玉洁
赵宁军
卓晓英
陈梦双
陈彬杰
冷丹丹
代春伟
FU Yujie;ZHAO Ningjun;ZHUO Xiaoying;CHEN Mengshuang;CHEN Binjie;LENG Dandan;DAI Chunwei(Department of Emergency Medicine,The Affiliated Hospital of Xuzhou Medical University,Xuzhou,Jiangsu 221002,China;Department of Ultrosound Medicine,The Affiliated Hospital of Xuzhou Medical University,Xuzhou,Jiangsu 221002,China;Xuzhou Key Laboratory of Emergency Medicine,The Affiliated Hospital of Xuzhou Medical University,Xuzhou,Jiangsu 221002,China)
出处
《安徽医药》
CAS
2024年第12期2372-2377,共6页
Anhui Medical and Pharmaceutical Journal
基金
徐州市国家临床重点专科培育项目(2018ZK004)
徐州市重点研发计划(社会发展)医药卫生面上项目(KC22232,KC22236)
徐州医科大学附属医院第三批优秀中青年人才项目(2021107408)。
关键词
脑梗死
卒中
全身免疫炎症指数
全身炎症反应指数
神经损伤
预后
Brain infarction
Stroke
Systemic immune inflammatory index
Systemic inflammatory response index
Nerve injury
The prognosis
