摘要
目的探讨祛浊化瘀通腑方联合重组组织型纤溶酶原激活剂(rt-PA)治疗急性缺血性脑卒中(AIS)的效果。方法选取2023年1月至12月佛山市中医院三水医院收治的100例风痰阻络腑实型AIS患者,男性55例,女性45例,年龄(57.86±8.27)岁,年龄范围为59~72岁。根据不同的治疗方法分为常规组(n=50)和观察组(n=50)。两组入院后均进行rt-PA静脉溶栓治疗,观察组在常规组基础上,加用祛浊化瘀通腑方。比较两组患者治疗前、治疗2周后的中医证候积分、美国国立卫生研究院卒中量表神经功能缺损评分(NIHSS)、改良Rankin量表评分(MRS)、改良Barthel指数评定量表(MBI)及治疗有效率。结果治疗前,两组的各项中医证候积分、NIHSS评分、MRS评分、MBI评分比较,差异无统计学意义(P>0.05);治疗后,两组各项积分、NIHSS评分、MRS评分均低于治疗前,且观察组低于常规组,差异有统计学意义(P<0.05);治疗后,两组的MBI评分高于治疗前,且观察组高于常规组,差异均有统计学意义(P<0.05)。观察组的治疗有效率为94.0%(47/50),显著高于常规组的76.0%(38/50),差异有统计学意义(P<0.05)。结论祛浊化瘀通腑方联合rt-PA治疗AIS效果显著,可显著降低中医证候积分,提高神经功能。
Objective To investigate the effect of Quzhuhuhuayutongfu recipe combined with recombinant tissue plasminogen activator(rt-PA)on intravenous thrombolytic therapy for acute ischemic stroke(AIS).Methods A total of 100 patients with wind-phlegm-blocked AIS were selected from the Sanshui Hospital,Foshan Hospital of Traditional Chinese Medicine from January to December 2023,including 55 males and 45 females,aged(57.86±8.27)years old,ranging form 59 to 72 years old.The patient were divided into conventional group(n=50)and observation group(n=50)according to different treatment methods.Both groups were treated with rt-PA intravenous thrombolytic therapy after admission.The observation group was additionally treated with Quzhuohuayu Tongfu prescription on the basis of the conventional group.TCM syndrome score,National Institutes of Health Stroke Scale Neurological Deficit score(NIHSS),modified Rankin Scale score(MRS),Modified Barthel Index Rating Scale(MBI)and total effective rate were compared between the two groups before treatment and 2 weeks after treatment.Results Before treatment,there was no significant difference in TCM syndrome scores,NIHSS scores,MRS Scores and MBI scores between the two groups(P>0.05).After treatment,all the scores,NIHSS scores and MRS Scores of the two groups were lower than before treatment,and the observation group was lower than the conventional group,with statistical significance(P<0.05).After treatment,the MBI score of the two groups was higher than that before treatment,and that of the observation group was higher than that of the conventional group,with statistical significance(P<0.05).The total effective rate of observation group was 94.0%(47/50),which was significantly higher than that of conventional group 76.0%(38/50),and the difference was statistically significant(P<0.05).Conclusion Quzhuhuhuayu Tongfu prescription combined with rt-PA intravenous thrombolytic therapy for AIS can significantly reduce TCM syndrome score and improve nerve function.
作者
刘锡坚
娄蕾
LIU Xi-jian;LOU Lei(Department of Encephalopathy,Sanshui Hospital,Foshan Hospital of Traditional Chinese Medicine,Foshan 528100,China)
出处
《创伤与急危重病医学》
2024年第6期383-386,共4页
Trauma and Critical Care Medicine
基金
佛山市自筹经费类科技创新项目入库培育项目(2220001004820)。
