摘要
目的:观察健脾化瘀通腑方治疗恶性淋巴瘤化疗后肠梗阻脾虚肠燥证临床效果。方法:105例恶性淋巴瘤化疗后肠梗阻脾虚肠燥证患者随机分为西医组53例、联合组52例。比较两组临床症状改善情况及脾虚肠燥证的中医证候积分变化、胃肠引流量,治疗前、治疗7 d后两组血清相关因子[二胺氧化酶(DAO)、D-乳酸(D-LC)]和免疫功能[T淋巴细胞亚群(CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))、补体(C3、C4)]水平。结果:联合组腹痛、腹胀缓解时间、首次排气及排便时间均短于西医组(P<0.05)。第1~7天,两组胃肠引流量呈下降趋势,且第3~6天联合组低于西医组(P<0.05)。治疗7 d后,两组纳差、倦怠乏力、面色萎黄评分及总积分、血清DAO、D-LC、CD8^(+)较治疗前降低,且联合组治疗后上述指标低于西医组(均P<0.05)。两组T淋巴细胞亚群(CD4^(+)、CD4^(+)/CD8^(+))、补体C3、C4较治疗前升高,且联合组治疗后高于西医组(均P<0.05)。结论:健脾化瘀通腑方能有效改善恶性淋巴瘤化疗后肠梗阻脾虚肠燥证的临床症状,提升免疫功能,修复损伤的肠黏膜屏障。
Objective:To observe clinical effects of Jianpi Huayu Tongfu decoction in treatment of patients with spleen deficiency and intestinal dryness obstruction after chemotherapy for malignant lymphoma.Methods:105 patients with intestinal obstruction with spleen deficiency and intestinal dryness after malignant lymphoma chemotherapy were randomly divided into western medicine group 53 cases and combined group 52 cases.The improvement status of clinical symptoms and TCM primary syndromes scores of spleen deficiency and intestinal dryness were compared between the two groups.The gastrointestinal drainage volume of the two groups were recorded,levels of serum-related factors[diamine oxidase(DAO),D-lactate(D-LC)]and immune function[T lymphocyte subsets(CD4^(+),CD8^(+),CD4^(+)/CD8^(+)),complements(C3,C4)]of the two groups were compared before and after 7 d of treatment.Results:The abdominal pain relief time,abdominal distension relief time,first exhaust time and defecation time in the combined group were all shorter than those in the western medicine group(P<0.05).From first day to seventh day,the gastrointestinal drainage volume in the two groups showed downward trend,and the volume in the combined group from third day to sixth day was less than that in the western medicine group(P<0.05).After 7 d of treatment,the scores of Nacha,Juandai Fali,Mianse Weihuang,total score and levels of serum DAO,D-LC and CD8^(+)in the two groups were significantly reduced compared with those before treatment.After treatment,the scores and levels were lower in the combined group than those in the western medicine group(all P<0.05).The T lymphocyte subsets(CD4^(+),CD4^(+)/CD8^(+))and complements C3 and C4 were significantly enhanced in the two groups compared to before treatment,and the levels in the combined group after treatment were higher than those in the western medicine group(all P<0.05).Conclusion:Jianpi Huayu Tongfu decoction can effectively improve clinical symptoms,enhance body’s immune function,repair damaged intestinal mucosal b
作者
王红英
方靖淞
WANG Hongying;FANG Jingsong(Meishan People’s Hospital,Meishan 620010,China)
出处
《陕西中医》
CAS
2024年第11期1512-1516,共5页
Shaanxi Journal of Traditional Chinese Medicine
基金
四川省科技厅重点研发项目(2020YFS0399)。
关键词
恶性淋巴瘤
肠梗阻
脾虚肠燥证
健脾化瘀通腑方
免疫功能
肠黏膜屏障
Malignant lymphoma
Intestinal obstruction
Spleen deficiency and intestinal dryness
Jianpi Huayu Tongfu decoction
Immune function
Intestinal mucosal barrier
