摘要
目的分析血清标记物对狼疮肾炎(LN)的预测价值。方法选定本院2022年6月至2023年12月就诊的90例系统性红斑狼疮(SLE)患者设为观察组,以及同期体检中心接诊的90名健康体检者设为健康组,检测血清白细胞介素-2(IL-2)、白细胞介素-6(IL-6),以间接荧光免疫法检测抗核抗体(抗ANA抗体)、抗核抗体谱(ANAs)15项,比较2组血清IL-2、IL-6、抗ANA抗体、抗ANAs抗体15项阳性率,根据患者是否发生LN将其分为2组,比较有、无LN组血清IL-2、IL-6、抗ANA抗体、抗ANAs抗体15项阳性率,绘制受试者工作曲线(ROC),分析血清IL-2、IL-6、抗ANA抗体、抗ANAs抗体15项对LN的预测价值。结果观察组血清IL-2水平低于健康组(P<0.05),观察组血清IL-6水平高于健康组(P<0.05)。观察组抗ANA抗体、抗线粒体抗M2型(抗ANA M2抗体)、抗核糖体P蛋白抗体(抗ARPA抗体)、抗组蛋白抗体(抗AHA抗体)、抗核小体抗体(抗AnuA抗体)、抗双链DNA抗体(抗ds-DNA抗体)、抗Ro-52抗体、抗干燥综合征A抗体(抗SSA抗体)、抗史密斯抗体(抗Sm抗体)、抗核糖核蛋白/斯密斯抗体(抗nRNP/Sm抗体)阳性率高于对照组(P<0.05),观察组抗增殖蛋白抗体(抗PCNA抗体)、抗着丝点抗体(抗CENPB抗体)、抗细胞质组酰-tRNA抗体(抗JO-1抗体)、抗PM-Scl抗体(抗PM-Scl抗体)、抗硬皮病70抗体(抗Scl-70抗体)、抗干燥综合征B抗体(抗SSB抗体)阳性率与对照组比较差异无统计学意义(P>0.05)。LN组血清IL-2水平低于无LN组(P<0.05),LN组血清IL-6水平均高于无LN组(P<0.05)。LN组抗ANA抗体、抗ANA M2抗体、抗ARPA抗、抗AHA抗体、抗AnuA抗体、抗ds-DNA抗体、抗Ro-52抗体、抗SSA抗体、抗Sm抗体、抗nRNP/Sm抗体阳性率高于无LN组(P<0.05),LN组抗PCNA抗、抗CENPB抗体、抗JO-1抗体、抗PM-Scl抗体、抗Scl-70抗体、抗SSB抗体阳性率与无LN组比较差异无统计学意义(P>0.05)。血清IL-2、IL-6、抗ANA抗体、抗ANA M2抗体、抗ARPA抗体、抗AHA抗体、抗AnuA�
Objective To analyze the predictive value of serum inflammatory factors,antinuclear antibody(ANA)and antinuclear antibody spectrum(ANAs)in lupus nephritis(LN).Methods A total of 90 patients with systemic lupus erythematosus(SLE)treated in our hospital from June 2022 to December 2023 were selected as the observation group,and 90 healthy subjects treated in the physical examination center during the same period were selected as the healthy group,and serum interleukin-2(IL-2)and interleukin-6(IL-6)were detected.ANA and ANAS 15 were detected by indirect fluorescence immunoassay,and the positive rates of serum IL-2,IL-6,ANA and ANAS 15 in the two groups were compared.Patients were divided into two groups according to whether they had LN,and the positive rates of serum IL-2,IL-6,ANA and ANAS 15 in the groups with and without LN were compared,and receiver operating curve(ROC)was drawn.The predictive value of serum IL-2,IL-6,ANA and ANAS for LN was analyzed.Results The serum IL-2 level in the observation group was lower than that in the healthy group(P<0.05),and the serum IL-6 level in the observation group was higher than that in the healthy group(P<0.05).The positive rates of ANA,ANA M2,ARPA,AHA,AnuA,ds-DNA,Ro-52,SSA,Sm and nRNP/Sm in observation group were higher than those in control group(P<0.05).The positive rates of PCNA,CENPB,JO-1,PM-Scl,Scl-70 and SSB in observation group were compared with those in control group(P>0.05).The serum IL-2 level in LN group was lower than that in no LN group(P<0.05),and the serum IL-6 level in LN group was higher than that in no LN group(P<0.05).The positive rates of ANA,ANA M2,ARPA,AHA,AnuA,ds-DNA,Ro-52,SSA,Sm and nRNP/Sm in LN group were higher than those in no LN group(P<0.05).The positive rates of PCNA,CENPB,JO-1,PM-Scl,Scl-70 and SSB in LN group were compared with those in no LN group(P>0.05).Serum IL-2,IL-6,ANA,ANA M2,ARPA,AHA,AnuA,ds-DNA,Ro-52,SSA,Sm,and nRNP/Sm combined detection predicted the AUC of LN to be 0.902,and the 95%confidence interval was 0.886 to 0.957.The sensit
作者
汤可
Tang Ke(Department of Laboratory Medicine,First People′s Hospital of Shangqiu City,Shangqiu 476100,China)
出处
《实用医技杂志》
2024年第9期626-631,共6页
Journal of Practical Medical Techniques
