摘要
抑郁症是以情绪低落为主要表现,伴有认知和行为改变的一种常见精神疾病。目前常用的抗抑郁药物起效缓慢、治疗周期长、复发率高,存在明显缺陷。经颅交流电刺激(transcranial alternating current stimulation,tACS)是一种非侵入性脑刺激技术,近年来逐渐应用于抑郁症的治疗中。抑郁症和大脑内源性神经振荡、突触可塑性的异常有关,tACS可以对以上机制产生影响,从而治疗抑郁症。不同频率的tACS刺激可以改善抑郁症状,其中以γ、α频率的刺激最受关注。本文主要对tACS的可能作用机制以及不同频率tACS在抑郁症中的应用进行综述,有助于进一步探讨tACS治疗抑郁症的可行性。
Depression is a common mental disorder characterized primarily by low mood accompanied by cognitive and behavioral changes.The commonly used antidepressants are not fast onset.Even with a long term pharmacotherapy,relapse rate is still quite high.Transcranial alternating current stimulation(tACS)is a non-invasive brain stimulation technique that has been increasingly used in the treatment of depression in recent years.Since depression is associated with abnormalities in endogenous neural oscillations and synaptic plasticity in the brain,tACS can influence these process,thereby treating depression.Different frequencies of tACS stimulation can improve depressive symptoms,with gamma(γ)and alpha(α)frequencies receiving the most attention.This article primarily reviews the potential mechanisms of tACS and the application of tACS at different frequencies in treating depression,aiming to further explore the feasibility of tACS in the treatment of depression.
作者
张雪琳
张兰
司夏樱
王克
黄佩姗
苗懿
董强利
Zhang Xuelin;Zhang Lan;Si Xiaying;Wang Ke;Huang Peishan;Miao Yi;Dong Qiangli(Department of Neurosurgery,Lanzhou University Second Hospital,Lanzhou 730000,China)
出处
《中华精神科杂志》
CAS
CSCD
北大核心
2024年第11期778-782,共5页
Chinese Journal of Psychiatry
基金
甘肃省自然科学基金(21JR1RA125)
中青年教学骨干培育项目(lzuyxcx-2022-205)
兰州大学第二医院“萃英科技创新”计划项目(CY2021-BJ-A15)。
关键词
抑郁症
经颅交流电刺激
神经振荡
频率
治疗
Depressive disorder
Transcranial alternating current stimulation
Neural oscillation
Frequency
Therapy
